Title |
The microbiome of the upper airways: focus on chronic rhinosinusitis
|
---|---|
Published in |
World Allergy Organization Journal, January 2015
|
DOI | 10.1186/s40413-014-0048-6 |
Pubmed ID | |
Authors |
Thanit Chalermwatanachai, Leydi Carolina Velásquez, Claus Bachert |
Abstract |
Upper airway diseases including allergic rhinitis, chronic rhinosinusitis with or without polyps, and cystic fibrosis are characterized by substantially different inflammatory profiles. Traditionally, studies on the association of specific bacterial patterns with inflammatory profiles of diseases had been dependent on bacterial culturing. In the past 30 years, molecular biology methods have allowed bacterial culture free studies of microbial communities, revealing microbiota much more diverse than previously recognized including those found in the upper airway. At presence, the study of the pathophysiology of upper airway diseases is necessary to establish the relationship between the microbiome and inflammatory patterns to find their clinical reflections and also their possible causal relationships. Such investigations may elucidate the path to therapeutic approaches in correcting an imbalanced microbiome. In the review we summarized techniques used and the current knowledge on the microbiome of upper airway diseases, the limitations and pitfalls, and identified areas of interest for further research. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 4 | 17% |
United States | 2 | 8% |
Argentina | 1 | 4% |
Spain | 1 | 4% |
Puerto Rico | 1 | 4% |
Colombia | 1 | 4% |
Ecuador | 1 | 4% |
United Kingdom | 1 | 4% |
Unknown | 12 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 20 | 83% |
Practitioners (doctors, other healthcare professionals) | 3 | 13% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 1% |
Thailand | 1 | 1% |
Canada | 1 | 1% |
Unknown | 79 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 21% |
Student > Ph. D. Student | 13 | 16% |
Student > Master | 12 | 15% |
Student > Bachelor | 8 | 10% |
Professor | 6 | 7% |
Other | 15 | 18% |
Unknown | 11 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 30% |
Agricultural and Biological Sciences | 20 | 24% |
Biochemistry, Genetics and Molecular Biology | 11 | 13% |
Immunology and Microbiology | 5 | 6% |
Chemistry | 3 | 4% |
Other | 3 | 4% |
Unknown | 15 | 18% |