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Host-Pathogen Interactions

Overview of attention for book
Cover of 'Host-Pathogen Interactions'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Genetic Association Studies in Host–Pathogen Interaction Analysis
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    Chapter 2 Bacterial Genotyping Methods: From the Basics to Modern
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    Chapter 3 Real-Time Reverse Transcription PCR as a Tool to Study Virulence Gene Regulation in Bacterial Pathogens
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    Chapter 4 Usage of a Bioluminescence Reporter System to Image Promoter Activity During Host Infection
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    Chapter 5 lacZ Reporter System as a Tool to Study Virulence Gene Regulation in Bacterial Pathogens
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    Chapter 6 Western Blotting Against Tagged Virulence Determinants to Study Bacterial Pathogenicity
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    Chapter 7 Molecular Methods to Analyze the Effect of Proteins Expressed by Salmonella During Its Intracellular Stage
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    Chapter 8 Organoids as a Model to Study Infectious Disease
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    Chapter 9 Surface Proteome Biotinylation Combined with Bioinformatic Tools as a Strategy for Predicting Pathogen Interacting Proteins
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    Chapter 10 Systems Biology Modeling to Study Pathogen–Host Interactions
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    Chapter 11 Phage Therapy: Various Perspectives on How to Improve the Art
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    Chapter 12 Application of RNA-seq and Bioimaging Methods to Study Microbe–Microbe Interactions and Their Effects on Biofilm Formation and Gene Expression
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    Chapter 13 Serial Dilution-Based Growth Curves and Growth Curve Synchronization for High-Resolution Time Series of Bacterial Biofilm Growth
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    Chapter 14 Detection of Bacterial Quorum Sensing Molecules
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    Chapter 15 Generating Chromosome-Located Transcriptional Fusions to Fluorescent Proteins for Single-Cell Gene Expression Analysis in Pseudomonas syringae
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    Chapter 16 Introduction of Genetic Material in Ralstonia solanacearum Through Natural Transformation and Conjugation
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    Chapter 17 In Vitro and In Vivo Secretion/Translocation Assays to Identify Novel Ralstonia solanacearum Type 3 Effectors
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    Chapter 18 Plant Pathogenicity Phenotyping of Ralstonia solanacearum Strains
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    Chapter 19 Methods to Quantify Biotic-Induced Stress in Plants
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    Chapter 20 From Sample to Data: Preparing, Obtaining, and Analyzing Images of Plant-Pathogen Interactions Using Confocal Microscopy
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    Chapter 21 Screening of c-di-GMP-Regulated Exopolysaccharides in Host Interacting Bacteria
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    Chapter 22 Primary Characterization of Small RNAs in Symbiotic Nitrogen-Fixing Bacteria
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    Chapter 23 A New, Nondestructive, Split-Root System for Local and Systemic Plant Responses Studies with Soybean
  25. Altmetric Badge
    Chapter 24 Methods for the Characterization of Plant-Growth Promoting Rhizobacteria
Attention for Chapter 11: Phage Therapy: Various Perspectives on How to Improve the Art
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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6 tweeters

Citations

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2 Dimensions

Readers on

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33 Mendeley
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Chapter title
Phage Therapy: Various Perspectives on How to Improve the Art
Chapter number 11
Book title
Host-Pathogen Interactions
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7604-1_11
Pubmed ID
Book ISBNs
978-1-4939-7603-4, 978-1-4939-7604-1
Authors

Stephen T. Abedon

Abstract

Use of phages as antibacterial agents has a long and, even, storied history. During that time much has been learned but, to a degree, also forgotten. As a consequence, today we experience a largely preclinical development of a field which already has been subject to substantial clinical practice. This development, as well, is now occurring within a much more rigorously regulated environment than previously had been the case. The consequence is not only a need to reinvent standards of practice but to do so within a more explicitly pharmacological context. Of particular concern is that the application of phages to bacterial infections does not always result in control of the latter, necessitating ongoing thought on how to refine treatment protocols. Here I consider a number of issues relevant to such refinement, focusing on areas which, in my opinion, phage therapy researchers-perhaps especially those new to the field-might struggle with. In order of presentation, I consider how best to describe phage therapy within publications toward achieving a more coherent literature, the importance of Poisson distributions along with killing titers toward understanding phage dosing, the associated importance of establishing sufficient phage numbers in situ to achieve adequate bacteria killing, various problems with the use of multiplicity of infection (MOI) as a description of phage dosing, how to anticipate the basic kinetics of phage-bacteria absorptive interactions, how to distinguish passive from active treatments, and basic approaches toward addressing disappointing efficacy outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 21%
Researcher 6 18%
Student > Ph. D. Student 5 15%
Student > Bachelor 3 9%
Professor > Associate Professor 3 9%
Other 4 12%
Unknown 5 15%
Readers by discipline Count As %
Immunology and Microbiology 8 24%
Agricultural and Biological Sciences 6 18%
Medicine and Dentistry 5 15%
Biochemistry, Genetics and Molecular Biology 3 9%
Veterinary Science and Veterinary Medicine 2 6%
Other 3 9%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2018.
All research outputs
#7,860,085
of 15,283,064 outputs
Outputs from Methods in molecular biology
#1,890
of 8,987 outputs
Outputs of similar age
#153,733
of 404,600 outputs
Outputs of similar age from Methods in molecular biology
#253
of 1,813 outputs
Altmetric has tracked 15,283,064 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,987 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1,813 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.