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Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood

Overview of attention for article published in Acta Neuropathologica Communications, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)

Mentioned by

blogs
1 blog

Citations

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7 Dimensions

Readers on

mendeley
33 Mendeley
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Title
Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood
Published in
Acta Neuropathologica Communications, September 2014
DOI 10.1186/s40478-014-0138-2
Pubmed ID
Authors

Christopher Hohmann, Bianca Milles, Michael Schinke, Michael Schroeter, Jochen Ulzheimer, Peter Kraft, Christoph Kleinschnitz, Paul V Lehmann, Stefanie Kuerten

Abstract

B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or plasmapheresis have been shown to be successful in a subset of patients. Here, patients with either relapsing-remitting (n = 24) or secondary progressive (n = 6) MS presenting with an acute clinical relapse were screened for their B cell reactivity to brain antigens and were re-tested three to nine months later. Enzyme-linked immunospot technique (ELISPOT) was used to identify brain-reactive B cells in peripheral blood mononuclear cells (PBMC) directly ex vivo and after 96 h of polyclonal stimulation. Clinical severity of symptoms was determined using the Expanded Disability Status Scale (EDSS).

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 15%
Researcher 5 15%
Student > Doctoral Student 5 15%
Student > Postgraduate 4 12%
Other 3 9%
Other 9 27%
Unknown 2 6%
Readers by discipline Count As %
Medicine and Dentistry 14 42%
Agricultural and Biological Sciences 6 18%
Neuroscience 3 9%
Immunology and Microbiology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 3 9%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2015.
All research outputs
#2,131,474
of 12,489,036 outputs
Outputs from Acta Neuropathologica Communications
#236
of 574 outputs
Outputs of similar age
#50,358
of 269,660 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 3 outputs
Altmetric has tracked 12,489,036 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 574 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,660 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them