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Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation

Overview of attention for article published in Thrombosis Journal, December 2017
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Title
Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation
Published in
Thrombosis Journal, December 2017
DOI 10.1186/s12959-017-0153-1
Pubmed ID
Authors

Anja Wiedswang Horjen, Ingebjørg Seljeflot, Trygve Berge, Pål Smith, Harald Arnesen, Arnljot Tveit

Abstract

Atrial fibrillation (AF) confers a hypercoagulable state; however, it is not clear whether restoration of sinus rhythm is associated with normalisation of markers of thrombogenesis. We studied the impact of sustained sinus rhythm on prothrombotic markers, and their predictive abilities in foreseeing rhythm outcome after cardioversion. In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion of persistent AF were randomised to receive candesartan or placebo for 3-6 weeks before and 6 months after cardioversion. Endogenous thrombin potential (ETP), prothrombin fragment 1 + 2 (F1 + 2) and D-dimer were measured before cardioversion and at end of study. These markers were also measured in a reference group comprising 49 subjects without AF. The markers remained unchanged in those 28 patients who maintained sinus rhythm. Discontinuation of warfarin treatment in a subset of 13 low-risk patients in sinus rhythm was associated with significantly higher levels of D-dimer and F1 + 2 compared to the reference group; D-dimer (456 ng/mL (276, 763) vs. 279 ng/mL (192, 348), p = 0.002) and F1 + 2 (700 pmol/L (345, 845) vs. 232 pmol/L (190, 281), p < 0.001). None of the markers were associated with rhythm outcome after electrical cardioversion. Sustained sinus rhythm for 6 months after cardioversion for AF had no impact on ETP, F1 + 2 or D-dimer levels. Discontinuation of warfarin in low-risk patients with sustained sinus rhythm was associated with significantly higher levels of D-dimer and F1 + 2 compared to the reference group. Our results suggest persistent hypercoagulability in AF patients despite long-term maintenance of sinus rhythm. The CAPRAF study was registered at clinicaltrials.gov (NCT00130975) in August 2005.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 22%
Librarian 1 11%
Other 1 11%
Student > Ph. D. Student 1 11%
Student > Bachelor 1 11%
Other 2 22%
Unknown 1 11%
Readers by discipline Count As %
Medicine and Dentistry 6 67%
Neuroscience 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
All research outputs
#12,943,426
of 23,015,156 outputs
Outputs from Thrombosis Journal
#157
of 327 outputs
Outputs of similar age
#203,641
of 441,976 outputs
Outputs of similar age from Thrombosis Journal
#5
of 8 outputs
Altmetric has tracked 23,015,156 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 327 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.