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Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer

Overview of attention for article published in Cancer Epidemiology, Biomarkers & Prevention, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

twitter
8 tweeters

Citations

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13 Dimensions

Readers on

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11 Mendeley
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Title
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer
Published in
Cancer Epidemiology, Biomarkers & Prevention, March 2018
DOI 10.1158/1055-9965.epi-17-0319
Pubmed ID
Authors

Jason E. Sandler, Huang, Nan Zhao, Weiwei Wu, Fangfang Liu, Shuangge Ma, Robert Udelsman, Yawei Zhang

Abstract

Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure. Using data and DNA samples from a Connecticut population-based case-control study performed in 2010-2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 single-nucleotide polymorphisms (SNPs) in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype-environment interaction between each SNP and ionizing radiation. Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (>10mm) in the additive-model. The gene-environment interaction analysis yielded 24 SNPs with P-interaction<0.05 for all thyroid cancer, 12 SNPs with P-interaction<0.05 for thyroid microcarcinoma, and 5 SNPs with P-interaction<0.05 for larger tumor. Germline variants in DNA repair genes are associated with thyroid cancer risk, and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk. Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 45%
Other 1 9%
Lecturer > Senior Lecturer 1 9%
Student > Master 1 9%
Researcher 1 9%
Other 0 0%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 18%
Environmental Science 1 9%
Psychology 1 9%
Medicine and Dentistry 1 9%
Chemistry 1 9%
Other 0 0%
Unknown 5 45%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2022.
All research outputs
#6,999,533
of 21,714,585 outputs
Outputs from Cancer Epidemiology, Biomarkers & Prevention
#1,871
of 4,428 outputs
Outputs of similar age
#159,722
of 443,364 outputs
Outputs of similar age from Cancer Epidemiology, Biomarkers & Prevention
#20
of 47 outputs
Altmetric has tracked 21,714,585 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,428 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,364 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.