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DNA Topoisomerases

Overview of attention for book
Cover of 'DNA Topoisomerases'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Type IA DNA Topoisomerases: A Universal Core and Multiple Activities
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    Chapter 2 Topoisomerase I and Genome Stability: The Good and the Bad
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    Chapter 3 DNA Topoisomerases as Targets for Antibacterial Agents
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    Chapter 4 DNA Supercoiling Measurement in Bacteria
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    Chapter 5 DNA Catenation Reveals the Dynamics of DNA Topology During Replication
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    Chapter 6 Mapping E. coli Topoisomerase IV Binding and Activity Sites
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    Chapter 7 The Use of Psoralen Photobinding to Study Transcription-Induced Supercoiling
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    Chapter 8 Immunoprecipitation of RNA:DNA Hybrids from Budding Yeast
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    Chapter 9 Detection of oriC-Independent Replication in Escherichia coli Cells
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    Chapter 10 Single-Molecule Magnetic Tweezer Analysis of Topoisomerases
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    Chapter 11 Synthesis of Hemicatenanes for the Study of Type IA Topoisomerases
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    Chapter 12 An Assay for Detecting RNA Topoisomerase Activity
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    Chapter 13 Studying TDP1 Function in DNA Repair
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    Chapter 14 Topoisomerase II Chromatin Immunoprecipitation
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    Chapter 15 Analyzing Mitotic Chromosome Structural Defects After Topoisomerase II Inhibition or Mutation
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    Chapter 16 Monitoring the DNA Topoisomerase II Checkpoint in Saccharomyces cerevisiae
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    Chapter 17 Studying Topoisomerase 1-Mediated Damage at Genomic Ribonucleotides
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    Chapter 18 A Fluorescence-Based Assay for Identification of Bacterial Topoisomerase I Poisons
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    Chapter 19 Fluoroquinolone-Gyrase-DNA Cleaved Complexes
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    Chapter 20 Detection of Topoisomerase Covalent Complexes in Eukaryotic Cells
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    Chapter 21 Visualization and Quantification of Topoisomerase–DNA Covalent Complexes Using the Trapped in Agarose Immunostaining (TARDIS) Assay
  23. Altmetric Badge
    Chapter 22 Study of Plasmid-Mediated Quinolone Resistance in Bacteria
Attention for Chapter 11: Synthesis of Hemicatenanes for the Study of Type IA Topoisomerases
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Chapter title
Synthesis of Hemicatenanes for the Study of Type IA Topoisomerases
Chapter number 11
Book title
DNA Topoisomerases
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7459-7_11
Pubmed ID
29177740
Book ISBNs
978-1-4939-7458-0, 978-1-4939-7459-7
Authors

Shun-Hsiao Lee, Tao-shih Hsieh, Grace Ee-Lu Siaw, Lee, Shun-Hsiao, Hsieh, Tao-shih, Siaw, Grace Ee-Lu

Abstract

Hemicatenane is a structure that forms when two DNA duplexes are physically linked through a single-stranded crossover. It is proposed to be an intermediate resulting from double Holliday junction (dHJ) dissolution, repair of replication stalled forks and late stage replication. Our previous study has shown that hemicatenane can be synthesized and dissolved in vitro by hyperthermophilic type IA topoisomerases. Here we present the protocol of hemicatenane synthesis and its structure detection by 2D agarose gel electrophoresis. The generated product can be used as a substrate to study the biochemical mechanism of hemicatenane processing reactions.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

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The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 100%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 100%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#20,458,307
of 23,015,156 outputs
Outputs from Methods in molecular biology
#9,940
of 13,156 outputs
Outputs of similar age
#378,178
of 442,344 outputs
Outputs of similar age from Methods in molecular biology
#1,193
of 1,498 outputs
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So far Altmetric has tracked 13,156 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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