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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
|
|---|---|
| Published in |
Nature Communications, January 2018
|
| DOI | 10.1038/s41467-017-02473-5 |
| Pubmed ID | |
| Authors |
Ye Chen, Joanne M. L. Ho, David L. Shis, Chinmaya Gupta, James Long, Daniel S. Wagner, William Ott, Krešimir Josić, Matthew R. Bennett |
| Abstract |
One challenge for synthetic biologists is the predictable tuning of genetic circuit regulatory components to elicit desired outputs. Gene expression driven by ligand-inducible transcription factor systems must exhibit the correct ON and OFF characteristics: appropriate activation and leakiness in the presence and absence of inducer, respectively. However, the dynamic range of a promoter (i.e., absolute difference between ON and OFF states) is difficult to control. We report a method that tunes the dynamic range of ligand-inducible promoters to achieve desired ON and OFF characteristics. We build combinatorial sets of AraC-and LasR-regulated promoters containing -10 and -35 sites from synthetic and Escherichia coli promoters. Four sequence combinations with diverse dynamic ranges were chosen to build multi-input transcriptional logic gates regulated by two and three ligand-inducible transcription factors (LacI, TetR, AraC, XylS, RhlR, LasR, and LuxR). This work enables predictable control over the dynamic range of regulatory components. |
X Demographics
The data shown below were collected from the profiles of 61 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 28% |
| United Kingdom | 16 | 26% |
| France | 3 | 5% |
| Italy | 2 | 3% |
| Ireland | 2 | 3% |
| Denmark | 1 | 2% |
| Netherlands | 1 | 2% |
| Indonesia | 1 | 2% |
| Israel | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 17 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 64% |
| Scientists | 21 | 34% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 362 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 362 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 107 | 30% |
| Researcher | 50 | 14% |
| Student > Master | 47 | 13% |
| Student > Bachelor | 45 | 12% |
| Student > Doctoral Student | 15 | 4% |
| Other | 29 | 8% |
| Unknown | 69 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 155 | 43% |
| Agricultural and Biological Sciences | 44 | 12% |
| Engineering | 23 | 6% |
| Chemical Engineering | 14 | 4% |
| Chemistry | 9 | 2% |
| Other | 29 | 8% |
| Unknown | 88 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 73. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2021.
All research outputs
#585,190
of 25,401,381 outputs
Outputs from Nature Communications
#10,077
of 56,991 outputs
Outputs of similar age
#13,508
of 450,468 outputs
Outputs of similar age from Nature Communications
#261
of 1,297 outputs
Altmetric has tracked 25,401,381 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,991 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,468 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,297 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.