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Evaluation of Chimerism Dynamics after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Nonmalignant Diseases

Overview of attention for article published in Biology of Blood & Marrow Transplantation, May 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

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11 Dimensions

Readers on

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21 Mendeley
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Title
Evaluation of Chimerism Dynamics after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Nonmalignant Diseases
Published in
Biology of Blood & Marrow Transplantation, May 2018
DOI 10.1016/j.bbmt.2017.12.801
Pubmed ID
Authors

Maura Faraci, Francesca Bagnasco, Massimiliano Leoni, Stefano Giardino, Paola Terranova, Lorenzo Subissi, Marco Di Duca, Daniela Di Martino, Edoardo Lanino

Abstract

It is recognized that chimerism following hematopoietic stem cell transplantation (HSCT) is a dynamic process. The aims of this study were to describe the evolution of chimerism in children with non-malignant diseases who underwent allogeneic HSCT, and to analyze the risk factors influencing chimerism status. 101 HSCTs were performed in 85 patients with non-malignant diseases. The donor was unrelated in 62.4% of HSCTs. Reduced intensity conditioning (RIC) regimen was administered in 48.5% of patients. Acute Graft-versus-Host Disease (a-GvHD) occurred in 51.7%, and chronic GvHD (c-GvHD) in 39.7% of patients. Analysis of chimerism was performed through amplification of nine specific short tandem repeats (STRs) by polymerase chain reaction (PCR) at engraftment and 1, 6 and 12 months after HSCT. Upon first evaluation, complete chimerism (CC) was detected in 34.7% and mixed chimerism (MC) in 55.4%, while graft failure occurred in 9.9% of patients. Severe a-GvHD was associated with CC (P=0.031). The last chimerism evaluation showed CC in 72.1%, stable mixed chimerism (SMC) in 12.8% and progressive mixed chimerism (PMC) in 3.5%. CC was associated with a higher incidence of a-GvHD (P=0.016) and c-GvHD (P=0.022), while the reduced-intensity conditioning regimen was associated with graft failure (P=0.026). One- and 3-year overall survival (OS) was 87.4% and 80.5% respectively, with a lower OS at 3 years in patients with CC compared to those with MC (P=0.008). Acute and chronic GvHD represent factors favoring CC, thus close, careful follow-up of chimerism is recommended in patients affected by non-malignant disease.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Other 3 14%
Student > Ph. D. Student 3 14%
Student > Master 3 14%
Student > Doctoral Student 2 10%
Other 1 5%
Unknown 5 24%
Readers by discipline Count As %
Medicine and Dentistry 11 52%
Immunology and Microbiology 3 14%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Engineering 1 5%
Other 0 0%
Unknown 4 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2021.
All research outputs
#2,631,814
of 16,920,965 outputs
Outputs from Biology of Blood & Marrow Transplantation
#385
of 2,976 outputs
Outputs of similar age
#81,150
of 414,088 outputs
Outputs of similar age from Biology of Blood & Marrow Transplantation
#12
of 76 outputs
Altmetric has tracked 16,920,965 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,976 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 414,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.