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Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis

Overview of attention for article published in Breast Cancer Research, December 2005
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Title
Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
Published in
Breast Cancer Research, December 2005
DOI 10.1186/bcr1368
Pubmed ID
Authors

Mark D Sternlicht

Abstract

Part of how the mammary gland fulfills its function of producing and delivering adequate amounts of milk is by forming an extensive tree-like network of branched ducts from a rudimentary epithelial bud. This process, termed branching morphogenesis, begins in fetal development, pauses after birth, resumes in response to estrogens at puberty, and is refined in response to cyclic ovarian stimulation once the margins of the mammary fat pad are met. Thus it is driven by systemic hormonal stimuli that elicit local paracrine interactions between the developing epithelial ducts and their adjacent embryonic mesenchyme or postnatal stroma. This local cellular cross-talk, in turn, orchestrates the tissue remodeling that ultimately produces a mature ductal tree. Although the precise mechanisms are still unclear, our understanding of branching in the mammary gland and elsewhere is rapidly improving. Moreover, many of these mechanisms are hijacked, bypassed, or corrupted during the development and progression of cancer. Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 426 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
United Kingdom 3 <1%
Brazil 1 <1%
Canada 1 <1%
Italy 1 <1%
Mexico 1 <1%
Singapore 1 <1%
Argentina 1 <1%
Poland 1 <1%
Other 0 0%
Unknown 412 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 24%
Researcher 55 13%
Student > Master 54 13%
Student > Bachelor 39 9%
Student > Doctoral Student 23 5%
Other 67 16%
Unknown 85 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 124 29%
Biochemistry, Genetics and Molecular Biology 110 26%
Medicine and Dentistry 49 12%
Engineering 9 2%
Pharmacology, Toxicology and Pharmaceutical Science 6 1%
Other 35 8%
Unknown 93 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2022.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Breast Cancer Research
#977
of 2,053 outputs
Outputs of similar age
#41,881
of 161,098 outputs
Outputs of similar age from Breast Cancer Research
#3
of 11 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,098 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.