Title |
Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain
|
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Published in |
BMC Neuroscience, February 2003
|
DOI | 10.1186/1471-2202-4-4 |
Pubmed ID | |
Authors |
Prasunpriya Nayak, Ajay K Chatterjee |
Abstract |
Alteration of glutamate and gamma-aminobutyrate system have been reported to be associated with neurodegenerative disorders and have been postulated to be involved in aluminum-induced neurotoxicity as well. Aluminum, an well known and commonly exposed neurotoxin, was found to alter glutamate and gamma-aminobutyrate levels as well as activities of associated enzymes with regional specificity. Protein malnutrition also reported to alter glutamate level and some of its metabolic enzymes. Thus the region-wise study of levels of brain glutamate and gamma-aminobutyrate system in protein adequacy and inadequacy may be worthwhile to understand the mechanism of aluminum-induced neurotoxicity. |
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