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Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice

Overview of attention for article published in Journal of Inflammation, January 2018
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Title
Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice
Published in
Journal of Inflammation, January 2018
DOI 10.1186/s12950-017-0178-z
Pubmed ID
Authors

Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu, Haige Ye

Abstract

Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis of GI aGVHD in practice. To date, no consensus plasma biomarker of GI aGVHD can be used to help make a diagnosis. Here, we attempted to identify GI aGVHD associated plasma proteins in murine model, which can help make a diagnosis of GI aGVHD. We used 8-plex isobaric tags for relative and absolute quantitation (8-plex iTRAQ) to screen out proteins in plasma samples taken from murine models before and after allogeneic HSCT. Next mRNA expressions were validated by quantitative real-time polymerase chain reaction in mouse intestinal epithelial samples. We found that five proteins were increased at least 2-fold in the allogeneic group at day 7 compared with days 0, 3 and 15 (after Cyclosporin A treatment) and the syngeneic group at day 7. These 5 proteins were VNN3, ZNF746, C4BP, KNG1 and FETUB, and they were consistent with results from negative labeling with 8-plex iTRAQ. Furthermore, increase in mRNA level of VNN3 was confirmed in murine intestinal epithelial samples with aGVHD. Our results demonstrate that plasma VNN3 protein is associated with GI aGVHD in murine model.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 25%
Student > Master 2 25%
Researcher 2 25%
Student > Ph. D. Student 1 13%
Student > Postgraduate 1 13%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 13%
Business, Management and Accounting 1 13%
Nursing and Health Professions 1 13%
Agricultural and Biological Sciences 1 13%
Computer Science 1 13%
Other 2 25%
Unknown 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2018.
All research outputs
#9,878,485
of 12,372,610 outputs
Outputs from Journal of Inflammation
#155
of 247 outputs
Outputs of similar age
#251,858
of 352,269 outputs
Outputs of similar age from Journal of Inflammation
#5
of 6 outputs
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So far Altmetric has tracked 247 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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