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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: Implications for a distinctive B cell developmental pathway in teleost fish
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2005
|
| DOI | 10.1073/pnas.0500027102 |
| Pubmed ID | |
| Authors |
John D. Hansen, Eric D. Landis, Ruth B. Phillips |
| Abstract |
During the analysis of Ig superfamily members within the available rainbow trout (Oncorhynchus mykiss) EST gene index, we identified a unique Ig heavy-chain (IgH) isotype. cDNAs encoding this isotype are composed of a typical IgH leader sequence and a VDJ rearranged segment followed by four Ig superfamily C-1 domains represented as either membrane-bound or secretory versions. Because teleost fish were previously thought to encode and express only two IgH isotypes (IgM and IgD) for their humoral immune repertoire, we isolated all three cDNA isotypes from a single homozygous trout (OSU-142) to confirm that all three are indeed independent isotypes. Bioinformatic and phylogenetic analysis indicates that this previously undescribed divergent isotype is restricted to bony fish, thus we have named this isotype "IgT" (tau) for teleost fish. Genomic sequence analysis of an OSU-142 bacterial artificial chromosome (BAC) clone positive for all three IgH isotypes revealed that IgT utilizes the standard rainbow trout V(H) families, but surprisingly, the IgT isotype possesses its own exclusive set of D(H) and J(H) elements for the generation of diversity. The IgT D and J segments and tau constant (C) region genes are located upstream of the D and J elements for IgM, representing a genomic IgH architecture that has not been observed in any other vertebrate class. All three isotypes are primarily expressed in the spleen and pronephros (bone marrow equivalent), and ontogenically, expression of IgT is present 4 d before hatching in developing embryos. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Spain | 2 | <1% |
| Austria | 1 | <1% |
| India | 1 | <1% |
| Norway | 1 | <1% |
| Mexico | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 197 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 23% |
| Researcher | 46 | 22% |
| Student > Master | 27 | 13% |
| Student > Bachelor | 16 | 8% |
| Student > Doctoral Student | 11 | 5% |
| Other | 31 | 15% |
| Unknown | 30 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 49% |
| Biochemistry, Genetics and Molecular Biology | 23 | 11% |
| Immunology and Microbiology | 21 | 10% |
| Veterinary Science and Veterinary Medicine | 7 | 3% |
| Medicine and Dentistry | 7 | 3% |
| Other | 6 | 3% |
| Unknown | 42 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2022.
All research outputs
#3,515,553
of 26,017,215 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#36,211
of 104,451 outputs
Outputs of similar age
#6,873
of 72,298 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#119
of 503 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 104,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,298 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.