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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Decoupling circadian clock protein turnover from circadian period determination
|
|---|---|
| Published in |
Science, January 2015
|
| DOI | 10.1126/science.1257277 |
| Pubmed ID | |
| Authors |
Luis F Larrondo, Consuelo Olivares-Yañez, Christopher L Baker, Jennifer J Loros, Jay C Dunlap |
| Abstract |
The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative feedback loop, wherein progressive and controlled phosphorylation of one or more negative elements ultimately elicits their own proteasome-mediated degradation, thereby releasing negative feedback and determining circadian period length. The Neurospora crassa circadian negative element FREQUENCY (FRQ) exemplifies such proteins; it is progressively phosphorylated at more than 100 sites, and strains bearing alleles of frq with anomalous phosphorylation display abnormal stability of FRQ that is well correlated with altered periods or apparent arrhythmicity. Unexpectedly, we unveiled normal circadian oscillations that reflect the allelic state of frq but that persist in the absence of typical degradation of FRQ. This manifest uncoupling of negative element turnover from circadian period length determination is not consistent with the consensus eukaryotic circadian model. |
X Demographics
The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 36% |
| United Kingdom | 3 | 6% |
| Germany | 3 | 6% |
| Egypt | 1 | 2% |
| Australia | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 21 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 60% |
| Scientists | 15 | 32% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Chile | 1 | <1% |
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 196 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 27% |
| Researcher | 40 | 19% |
| Student > Bachelor | 31 | 15% |
| Professor | 11 | 5% |
| Student > Doctoral Student | 11 | 5% |
| Other | 33 | 16% |
| Unknown | 26 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 77 | 37% |
| Biochemistry, Genetics and Molecular Biology | 50 | 24% |
| Medicine and Dentistry | 11 | 5% |
| Neuroscience | 6 | 3% |
| Chemistry | 6 | 3% |
| Other | 20 | 10% |
| Unknown | 38 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#557,230
of 25,249,294 outputs
Outputs from Science
#12,382
of 80,725 outputs
Outputs of similar age
#7,223
of 365,011 outputs
Outputs of similar age from Science
#294
of 1,112 outputs
Altmetric has tracked 25,249,294 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,112 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.