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Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, June 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
30 Mendeley
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Title
Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer
Published in
Journal of Experimental & Clinical Cancer Research, June 2009
DOI 10.1186/1756-9966-28-84
Pubmed ID
Authors

Maulik R Shah, Christopher L Kriedt, Nathan H Lents, Mary K Hoyer, Nimah Jamaluddin, Claudette Klein, Joseph Baldassare

Abstract

Intracellular levels of zinc have shown a strong inverse correlation to growth and malignancy of prostate cancer. To date, studies of zinc supplementation in prostate cancer have been equivocal and have not accounted for bioavailability of zinc. Therefore, we hypothesized that direct intra-tumoral injection of zinc could impact prostate cancer growth. In this study, we evaluated the cytotoxic properties of the pH neutral salt zinc acetate on the prostate cancer cell lines PC3, DU145 and LNCaP. Zinc acetate killed prostate cancer cell lines in vitro, independent of androgen sensitivity, in a dose-dependent manner in a range between 200 and 600 microM. Cell death occurred rapidly with 50% cell death by six hours and maximal cell death by 18 hours. We next established a xenograft model of prostate cancer and tested an experimental treatment protocol of direct intra-tumoral injection of zinc acetate. We found that zinc treatments halted the growth of the prostate cancer tumors and substantially extended the survival of the animals, whilst causing no detectable cytoxicity to other tissues. Thus, our studies form a solid proof-of-concept that direct intra-tumoral injection of zinc acetate could be a safe and effective treatment strategy for prostate cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 23%
Student > Master 6 20%
Researcher 4 13%
Student > Ph. D. Student 4 13%
Professor 3 10%
Other 4 13%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Biochemistry, Genetics and Molecular Biology 3 10%
Engineering 3 10%
Chemistry 3 10%
Medicine and Dentistry 2 7%
Other 2 7%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
All research outputs
#4,407,484
of 21,673,824 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#186
of 1,923 outputs
Outputs of similar age
#63,841
of 323,905 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#1
of 5 outputs
Altmetric has tracked 21,673,824 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,923 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,905 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them