Chapter title |
Utility of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Preclinical Evaluation of Therapies in Cancer
|
---|---|
Chapter number | 3 |
Book title |
Inflammation and Cancer
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7568-6_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7567-9, 978-1-4939-7568-6
|
Authors |
William Berry, Daniel Croagh |
Abstract |
Personalising cancer therapy is a way of improving treatment efficacy, by selecting specific treatments for patients with certain molecular changes to their tumour. This requires both molecular material to detect these targets and a preclinical disease model to demonstrate treatment efficacy. In pancreatic cancer this is problematic, as most patients present with advanced disease and are therefore ineligible for surgery. As a result, biological material derived from such patients has been excluded from all preclinical studies in personalised medicine. This chapter presents methodology to achieve both of the above-mentioned requirements using endoscopic ultrasound-guided fine-needle aspiration, which can be offered to nearly all patients with early or advanced disease. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 4 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 1 | 25% |
Professor | 1 | 25% |
Student > Bachelor | 1 | 25% |
Unknown | 1 | 25% |
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Nursing and Health Professions | 1 | 25% |
Medicine and Dentistry | 1 | 25% |
Unknown | 2 | 50% |