Chapter title |
Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer
|
---|---|
Chapter number | 11 |
Book title |
Inflammation and Cancer
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7568-6_11 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7567-9, 978-1-4939-7568-6
|
Authors |
Christoph Garbers, Stefan Rose-John |
Abstract |
Interleukin-6 is a cytokine synthesized by many cells in the human body. IL-6 binds to a membrane bound IL-6R, which is only present on hepatocytes, some epithelial cells and some leukocytes. The complex of IL-6 and IL-6R binds to the ubiquitously expressed receptor subunit gp130, which forms a homodimer and thereby initiates intracellular signaling via the JAK/STAT and the MAPK pathways. IL-6R expressing cells can cleave the receptor protein to generate a soluble IL-6R (sIL-6R), which can still bind IL-6 and can associate with gp130 and induce signaling even on cells, which do not express IL-6R. This paradigm has been called IL-6 trans-signaling whereas signaling via the membrane bound IL-6R is referred to as classic signaling. We have generated several molecular tools to differentiate between IL-6 classic- and trans-signaling and to analyze the consequence of cellular IL-6 signaling in vivo. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 21% |
Student > Ph. D. Student | 7 | 16% |
Student > Doctoral Student | 4 | 9% |
Researcher | 4 | 9% |
Other | 2 | 5% |
Other | 4 | 9% |
Unknown | 13 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 30% |
Medicine and Dentistry | 7 | 16% |
Agricultural and Biological Sciences | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 2 | 5% |
Unknown | 14 | 33% |