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The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis

Overview of attention for article published in Journal of Veterinary Medical Science, January 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

twitter
7 tweeters

Citations

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2 Dimensions

Readers on

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11 Mendeley
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Title
The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis
Published in
Journal of Veterinary Medical Science, January 2018
DOI 10.1292/jvms.17-0483
Pubmed ID
Authors

Atsushi TSUKAMOTO, Minami OHGODA, Nozomi HARUKI, Masatoshi HORI, Tomo INOMATA

Abstract

The neurokinin 1 receptor (NK1R) plays an important role in the pathogenesis of acute pancreatitis (AP). Maropitant is an NK1R antagonist that is widely used as an antiemetic in dogs and cats. In the present study, we investigated the anti-inflammatory action of maropitant in a mouse model of AP. AP was induced in BALB/c mice by intraperitoneal administration of cerulein, and maropitant was administered subcutaneously at a dose of 8 mg/kg. We assessed the mRNA expression levels of NK1R and substance P (SP) in the pancreatic tissue via real-time reverse transcription polymerase chain reaction. In addition, the effect of maropitant on plasma amylase, lipase, and interleukin-6 (IL-6) levels was measured in each mouse. Inflammatory cell infiltration in the pancreas was assessed by myeloperoxidase (MPO) staining. Our results showed that AP induction significantly elevated the mRNA expression of SP in the pancreatic tissue. Treatment with maropitant significantly lowered plasma amylase and IL-6 levels. In addition, treatment with maropitant inhibited the infiltration of MPO-positive cells in the pancreas. The present study suggests that maropitant possesses an anti-inflammatory activity, in addition to its antiemetic action.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 27%
Researcher 2 18%
Student > Postgraduate 2 18%
Student > Bachelor 1 9%
Student > Ph. D. Student 1 9%
Other 2 18%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 55%
Agricultural and Biological Sciences 2 18%
Medicine and Dentistry 2 18%
Unspecified 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2018.
All research outputs
#3,335,986
of 13,453,142 outputs
Outputs from Journal of Veterinary Medical Science
#101
of 2,409 outputs
Outputs of similar age
#100,377
of 348,292 outputs
Outputs of similar age from Journal of Veterinary Medical Science
#8
of 276 outputs
Altmetric has tracked 13,453,142 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,409 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,292 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 276 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.