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A perspective on multi‐target drug discovery and design for complex diseases

Overview of attention for article published in Clinical and Translational Medicine, January 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

news
2 news outlets
twitter
8 X users

Citations

dimensions_citation
489 Dimensions

Readers on

mendeley
617 Mendeley
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Title
A perspective on multi‐target drug discovery and design for complex diseases
Published in
Clinical and Translational Medicine, January 2018
DOI 10.1186/s40169-017-0181-2
Pubmed ID
Authors

Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi

Abstract

Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 617 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 617 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 94 15%
Researcher 80 13%
Student > Master 65 11%
Student > Bachelor 64 10%
Unspecified 47 8%
Other 106 17%
Unknown 161 26%
Readers by discipline Count As %
Chemistry 101 16%
Biochemistry, Genetics and Molecular Biology 77 12%
Pharmacology, Toxicology and Pharmaceutical Science 75 12%
Unspecified 47 8%
Agricultural and Biological Sciences 39 6%
Other 71 12%
Unknown 207 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#1,618,670
of 25,382,440 outputs
Outputs from Clinical and Translational Medicine
#59
of 1,060 outputs
Outputs of similar age
#37,333
of 451,258 outputs
Outputs of similar age from Clinical and Translational Medicine
#4
of 10 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,258 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.