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Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer

Overview of attention for article published in Nature Communications, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
10 news outlets
blogs
2 blogs
twitter
31 tweeters
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
45 Mendeley
Title
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
Published in
Nature Communications, January 2018
DOI 10.1038/s41467-017-02758-9
Pubmed ID
Authors

Nalinikanth Kotagiri, Matthew L. Cooper, Michael Rettig, Christopher Egbulefu, Julie Prior, Grace Cui, Partha Karmakar, Mingzhou Zhou, Xiaoxia Yang, Gail Sudlow, Lynne Marsala, Chantiya Chanswangphuwana, Lan Lu, LeMoyne Habimana-Griffin, Monica Shokeen, Xinming Xu, Katherine Weilbaecher, Michael Tomasson, Gregory Lanza, John F. DiPersio, Samuel Achilefu

Abstract

Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment of disseminated cancer by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and a contact-facilitated nanomicelle technology enabled highly selective delivery and co-localization of titanocene and radiolabelled fluorodeoxyglucose in disseminated multiple myeloma cells. Selective ablation of the cancer cells was achieved without significant off-target toxicity to the resident stem cells. Genomic, proteomic and multimodal imaging analyses revealed that the downregulation of CD49d, one of the dimeric protein targets of the nanomicelles, caused therapy resistance in small clusters of cancer cells. Similar treatment of a highly metastatic breast cancer model using human serum albumin-titanocene formulation significantly inhibited cancer growth. This strategy expands the use of phototherapy for treating previously inaccessible metastatic disease.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 22%
Researcher 10 22%
Other 5 11%
Student > Bachelor 4 9%
Student > Doctoral Student 3 7%
Other 8 18%
Unknown 5 11%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 16%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 5 11%
Engineering 4 9%
Agricultural and Biological Sciences 4 9%
Other 11 24%
Unknown 7 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 94. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2019.
All research outputs
#208,251
of 15,056,481 outputs
Outputs from Nature Communications
#3,636
of 28,282 outputs
Outputs of similar age
#8,415
of 362,688 outputs
Outputs of similar age from Nature Communications
#3
of 100 outputs
Altmetric has tracked 15,056,481 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 28,282 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.