Title |
Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
|
---|---|
Published in |
Nature Communications, January 2018
|
DOI | 10.1038/s41467-017-02677-9 |
Pubmed ID | |
Authors |
Huating Li, Guangyu Wu, Qichen Fang, Mingliang Zhang, Xiaoyan Hui, Bin Sheng, Liang Wu, Yuqian Bao, Peng Li, Aimin Xu, Weiping Jia |
Abstract |
Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 levels positively correlate with the SAT area in insulin-sensitive obese individuals. FGF21 knockout mice (FGF21KO) show less SAT mass and are more insulin-resistant when fed a high-fat diet. Replenishment of recombinant FGF21 to a level equivalent to that in obesity restores SAT mass and reverses insulin resistance in FGF21KO, but not in adipose-specific βklotho knockout mice. Moreover, transplantation of SAT from wild-type to FGF21KO mice improves insulin sensitivity in the recipients. Mechanistically, circulating FGF21 upregulates adiponectin in SAT, accompanied by an increase of M2 macrophage polarization. We propose that elevated levels of endogenous FGF21 in obesity serve as a defense mechanism to protect against systemic insulin resistance. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 17% |
Spain | 2 | 11% |
Canada | 2 | 11% |
United States | 2 | 11% |
Australia | 1 | 6% |
Unknown | 8 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 67% |
Scientists | 6 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 129 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 21 | 16% |
Researcher | 19 | 15% |
Student > Ph. D. Student | 12 | 9% |
Student > Master | 12 | 9% |
Student > Doctoral Student | 7 | 5% |
Other | 21 | 16% |
Unknown | 37 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 32 | 25% |
Medicine and Dentistry | 26 | 20% |
Agricultural and Biological Sciences | 14 | 11% |
Sports and Recreations | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 12 | 9% |
Unknown | 38 | 29% |