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Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach

Overview of attention for article published in Scientific Reports, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 40,229)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
181 Mendeley
citeulike
1 CiteULike
Title
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach
Published in
Scientific Reports, January 2015
DOI 10.1038/srep08126
Pubmed ID
Authors

Dirk W. Lachenmeier, Jürgen Rehm, Lachenmeier DW, Rehm J

Abstract

A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg bodyweight for heroin to 531 mg/kg bodyweight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the "high risk" category with MOE < 10, the rest of the compounds except THC fall into the "risk" category with MOE < 100. On a population scale, only alcohol would fall into the "high risk" category, and cigarette smoking would fall into the "risk" category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy, and benzodiazepines) had MOEs > 100, and cannabis had a MOE > 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco (high risk) and cannabis (low risk).

Twitter Demographics

The data shown below were collected from the profiles of 1,003 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 4%
Brazil 2 1%
United Kingdom 2 1%
Germany 1 <1%
France 1 <1%
Italy 1 <1%
South Africa 1 <1%
Norway 1 <1%
Netherlands 1 <1%
Other 5 3%
Unknown 159 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 42 23%
Student > Bachelor 29 16%
Student > Ph. D. Student 27 15%
Student > Master 22 12%
Other 15 8%
Other 46 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 20%
Medicine and Dentistry 29 16%
Psychology 26 14%
Social Sciences 21 12%
Neuroscience 10 6%
Other 58 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1395. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2017.
All research outputs
#915
of 8,658,872 outputs
Outputs from Scientific Reports
#16
of 40,229 outputs
Outputs of similar age
#33
of 243,599 outputs
Outputs of similar age from Scientific Reports
#1
of 1,082 outputs
Altmetric has tracked 8,658,872 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 40,229 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,599 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,082 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.