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Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach

Overview of attention for article published in Scientific Reports, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 80,973)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

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76 Dimensions

Readers on

mendeley
302 Mendeley
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1 CiteULike
Title
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach
Published in
Scientific Reports, January 2015
DOI 10.1038/srep08126
Pubmed ID
Authors

Dirk W. Lachenmeier, Jürgen Rehm

Abstract

A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg bodyweight for heroin to 531 mg/kg bodyweight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the "high risk" category with MOE < 10, the rest of the compounds except THC fall into the "risk" category with MOE < 100. On a population scale, only alcohol would fall into the "high risk" category, and cigarette smoking would fall into the "risk" category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy, and benzodiazepines) had MOEs > 100, and cannabis had a MOE > 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco (high risk) and cannabis (low risk).

Twitter Demographics

The data shown below were collected from the profiles of 1,167 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 302 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
Italy 1 <1%
Switzerland 1 <1%
France 1 <1%
Norway 1 <1%
Germany 1 <1%
Brazil 1 <1%
South Africa 1 <1%
Canada 1 <1%
Other 2 <1%
Unknown 286 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 58 19%
Student > Master 46 15%
Student > Ph. D. Student 44 15%
Student > Bachelor 43 14%
Other 21 7%
Other 56 19%
Unknown 34 11%
Readers by discipline Count As %
Medicine and Dentistry 54 18%
Agricultural and Biological Sciences 39 13%
Psychology 35 12%
Social Sciences 29 10%
Biochemistry, Genetics and Molecular Biology 18 6%
Other 79 26%
Unknown 48 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1657. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2020.
All research outputs
#2,210
of 15,577,666 outputs
Outputs from Scientific Reports
#32
of 80,973 outputs
Outputs of similar age
#27
of 288,553 outputs
Outputs of similar age from Scientific Reports
#1
of 6 outputs
Altmetric has tracked 15,577,666 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them