Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach

Overview of attention for article published in Scientific Reports, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 27,946)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
43 news outlets
blogs
8 blogs
policy
1 policy source
twitter
931 tweeters
peer_reviews
1 peer review site
facebook
112 Facebook pages
wikipedia
1 Wikipedia page
googleplus
40 Google+ users
reddit
3 Redditors

Readers on

mendeley
147 Mendeley
citeulike
1 CiteULike
Title
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach
Published in
Scientific Reports, January 2015
DOI 10.1038/srep08126
Pubmed ID
Authors

Dirk W. Lachenmeier, Jürgen Rehm, Lachenmeier DW, Rehm J

Abstract

A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg bodyweight for heroin to 531 mg/kg bodyweight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the "high risk" category with MOE < 10, the rest of the compounds except THC fall into the "risk" category with MOE < 100. On a population scale, only alcohol would fall into the "high risk" category, and cigarette smoking would fall into the "risk" category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy, and benzodiazepines) had MOEs > 100, and cannabis had a MOE > 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco (high risk) and cannabis (low risk).

Twitter Demographics

The data shown below were collected from the profiles of 931 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 5%
Germany 2 1%
Brazil 2 1%
United Kingdom 2 1%
France 1 <1%
Italy 1 <1%
South Africa 1 <1%
Norway 1 <1%
Netherlands 1 <1%
Other 5 3%
Unknown 124 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 38 26%
Student > Ph. D. Student 25 17%
Student > Master 20 14%
Student > Bachelor 18 12%
Other 11 7%
Other 35 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 24%
Medicine and Dentistry 27 18%
Psychology 22 15%
Social Sciences 19 13%
Chemistry 8 5%
Other 36 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1263. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2017.
All research outputs
#778
of 7,437,750 outputs
Outputs from Scientific Reports
#11
of 27,946 outputs
Outputs of similar age
#40
of 235,318 outputs
Outputs of similar age from Scientific Reports
#1
of 1,073 outputs
Altmetric has tracked 7,437,750 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,946 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,073 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.