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Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20165854
Pubmed ID
Authors

L. Santos, A.P. Davel, T.I.R. Almeida, M.R. Almeida, E.A. Soares, G.J.M. Fernandes, S.F. Magalhães, V.G. Barauna, J.A.D. Garcia

Abstract

Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion progression and left ventricle hypertrophy in LDLr-/- mice. These beneficial effects of soy milk and simvastatin were associated with reduced oxidative stress and inflammatory state in the heart and aorta caused by the hyperlipidic diet. Treatment with soy milk was more effective in preventing HDLc reduction and triacylglycerol and VLDLc increase. On the other hand, simvastatin was more effective in preventing an increase in total cholesterol, LDLc and superoxide production in aorta, as well as CD40L both in aorta and left ventricle of LDLr-/-. In conclusion, our results suggest a cardioprotective effect of soy milk in LDLr-/- mice comparable to the well-known effects of simvastatin.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 28%
Student > Master 3 12%
Professor > Associate Professor 2 8%
Researcher 2 8%
Student > Ph. D. Student 2 8%
Other 4 16%
Unknown 5 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 24%
Medicine and Dentistry 5 20%
Biochemistry, Genetics and Molecular Biology 3 12%
Nursing and Health Professions 2 8%
Neuroscience 1 4%
Other 0 0%
Unknown 8 32%