Title |
Tumour-stroma interactions: Phenotypic and genetic alterations in mammary stroma: implications for tumour progression
|
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Published in |
Breast Cancer Research, December 2001
|
DOI | 10.1186/bcr325 |
Pubmed ID | |
Authors |
Seth L Schor, Ana M Schor |
Abstract |
In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
United States | 1 | 4% |
Canada | 1 | 4% |
Unknown | 25 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 18% |
Researcher | 5 | 18% |
Professor > Associate Professor | 4 | 14% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 3 | 11% |
Other | 7 | 25% |
Unknown | 1 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 50% |
Biochemistry, Genetics and Molecular Biology | 7 | 25% |
Medicine and Dentistry | 4 | 14% |
Chemistry | 1 | 4% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 1 | 4% |