Title |
Derivation of genetic interaction networks from quantitative phenotype data
|
---|---|
Published in |
Genome Biology, March 2005
|
DOI | 10.1186/gb-2005-6-4-r38 |
Pubmed ID | |
Authors |
Becky L Drees, Vesteinn Thorsson, Gregory W Carter, Alexander W Rives, Marisa Z Raymond, Iliana Avila-Campillo, Paul Shannon, Timothy Galitski |
Abstract |
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 4% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Slovenia | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 109 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 38 | 32% |
Student > Ph. D. Student | 23 | 19% |
Professor > Associate Professor | 14 | 12% |
Student > Master | 11 | 9% |
Student > Bachelor | 10 | 8% |
Other | 14 | 12% |
Unknown | 10 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 59 | 49% |
Biochemistry, Genetics and Molecular Biology | 15 | 13% |
Computer Science | 14 | 12% |
Medicine and Dentistry | 6 | 5% |
Engineering | 4 | 3% |
Other | 7 | 6% |
Unknown | 15 | 13% |