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Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Overview of attention for article published in Anais da Academia Brasileira de Ciências, June 2017
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Title
Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow
Published in
Anais da Academia Brasileira de Ciências, June 2017
DOI 10.1590/0001-3765201720150797
Pubmed ID
Authors

SUSY R. LEMES, DWIGHT A. CHAVES, NELSON J. DA SILVA JÚNIOR, CRISTIENE C. CARNEIRO, LEE CHEN-CHEN, LUCIANE M. DE ALMEIDA, PABLO J. GONÇALVES, PAULO R. DE MELO-REIS

Abstract

The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct- and indirect-acting chemical mutagens, in a mammalian model.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Professor 2 5%
Researcher 2 5%
Student > Master 2 5%
Other 2 5%
Unknown 29 67%
Readers by discipline Count As %
Chemistry 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Physics and Astronomy 2 5%
Agricultural and Biological Sciences 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 3 7%
Unknown 31 72%