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In vitro antifungal activity of Myracrodruon urundeuva Allemão against human vaginal Candida species

Overview of attention for article published in Anais da Academia Brasileira de Ciências, July 2017
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Title
In vitro antifungal activity of Myracrodruon urundeuva Allemão against human vaginal Candida species
Published in
Anais da Academia Brasileira de Ciências, July 2017
DOI 10.1590/0001-3765201720170254
Pubmed ID
Authors

FERNANDO A. DE OLIVEIRA, VANESSA C. RORATO, ADRIANA A. ALMEIDA-APOLONIO, ALLAN B. RODRIGUES, ALINE L. DE BARROS, ANDRÉIA SANGALLI, ARIELLE C. ARENA, JONAS S. MOTA, ALEXÉIA B. GRISOLIA, KELLY M.P. DE OLIVEIRA

Abstract

Myracrodruon urundeuva is a plant native to Brazil, which is used by the indigenous population for the treatment of candidiasis. The aims of this study were to evaluate the antifungal activity of extract against human vaginal Candida species and evaluate the possible toxicological activities of M. urundeuva. Initially, ethanol extracts, ethyl acetate fractions, and hydroalcoholic fractions of the bark and leaf of M. urundeuva were used to determine the minimum inhibitory concentration. The extracts that showed antifungal activity were characterized by liquid chromatography and subjected to toxicity assessment. Toxic, cytotoxic, genotoxic, and mutagenic testing were performed using Allium cepa and Ames assays with the ethanol extracts of the bark and leaves. Hemolytic activity was evaluated in erythrocytes and acute toxicity in rats. The ethanol bark extracts showed best activity against Candida albicans, C. krusei, and C. tropicalis ATCC (4-512 µg/mL). Chemical characterization indicated the presence of flavonoids and tannins in the extracts. Hemolytic activity, genotoxicity, and mutagenicity were not observed. The results of the Ames and A. cepa tests were also in agreement, ethanol bark extracts and ethanol leaf extracts of M. urundeuva showed absence of mutagenic activity. Similar results were observed in the A. cepa assay and acute toxicity test in rats. M. urundeuva bark extracts showed potential for the treatment of vaginal infections caused Candida species, as a topical.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 21%
Student > Bachelor 5 18%
Student > Doctoral Student 2 7%
Other 2 7%
Researcher 2 7%
Other 5 18%
Unknown 6 21%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 21%
Medicine and Dentistry 5 18%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 2 7%
Business, Management and Accounting 1 4%
Other 2 7%
Unknown 8 29%