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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
|
|---|---|
| Published in |
Malaria Journal, October 2006
|
| DOI | 10.1186/1475-2875-5-84 |
| Pubmed ID | |
| Authors |
Peter E Meissner, Germain Mandi, Boubacar Coulibaly, Steffen Witte, Théophile Tapsoba, Ulrich Mansmann, Jens Rengelshausen, Wolfgang Schiek, Albrecht Jahn, Ingeborg Walter-Sack, Gerd Mikus, Jürgen Burhenne, Klaus-Dieter Riedel, R Heiner Schirmer, Bocar Kouyaté, Olaf Müller |
| Abstract |
The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 127 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 13% |
| Student > Master | 17 | 13% |
| Student > Ph. D. Student | 15 | 11% |
| Other | 12 | 9% |
| Student > Bachelor | 11 | 8% |
| Other | 28 | 21% |
| Unknown | 31 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 19% |
| Chemistry | 20 | 15% |
| Agricultural and Biological Sciences | 15 | 11% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Physics and Astronomy | 5 | 4% |
| Other | 21 | 16% |
| Unknown | 39 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2021.
All research outputs
#2,693,664
of 24,620,470 outputs
Outputs from Malaria Journal
#562
of 5,765 outputs
Outputs of similar age
#5,415
of 70,930 outputs
Outputs of similar age from Malaria Journal
#3
of 11 outputs
Altmetric has tracked 24,620,470 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,765 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.