Title |
Fighting against kidney diseases with small interfering RNA: opportunities and challenges
|
---|---|
Published in |
Journal of Translational Medicine, February 2015
|
DOI | 10.1186/s12967-015-0387-2 |
Pubmed ID | |
Authors |
Cheng Yang, Chao Zhang, Zitong Zhao, Tongyu Zhu, Bin Yang |
Abstract |
The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 19% |
Researcher | 5 | 16% |
Student > Master | 4 | 13% |
Student > Bachelor | 4 | 13% |
Professor > Associate Professor | 3 | 10% |
Other | 3 | 10% |
Unknown | 6 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Medicine and Dentistry | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Linguistics | 2 | 6% |
Other | 5 | 16% |
Unknown | 6 | 19% |