Title |
Dual Ligand‐Enabled Nondirected C−H Olefination of Arenes
|
---|---|
Published in |
Angewandte Chemie. International Edition, January 2018
|
DOI | 10.1002/anie.201712235 |
Pubmed ID | |
Authors |
Hao Chen, Philipp Wedi, Tim Meyer, Ghazal Tavakoli, Manuel van Gemmeren |
Abstract |
The applicability of the Pd-catalyzed oxidative C-H olefination of arenes, also known as the Fujiwara-Moritani reaction, has traditionally been limited by the requirement for directing groups on the substrate or the need to use the arene in large excess, typically as (co)solvent. Herein we report the development of a catalytic system that, through the combined action of two complimentary ligands, enables the use of directing group free arenes as limiting reagents for the first time. The reactions proceed under a combination of both steric and electronic control and enable the application of this powerful reaction to valuable arenes, which cannot be utilized in excess. |
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Country | Count | As % |
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Germany | 4 | 40% |
United States | 3 | 30% |
Sweden | 1 | 10% |
Brazil | 1 | 10% |
Unknown | 1 | 10% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 60% |
Scientists | 3 | 30% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 24% |
Student > Master | 12 | 17% |
Student > Bachelor | 9 | 13% |
Researcher | 7 | 10% |
Professor | 3 | 4% |
Other | 5 | 7% |
Unknown | 17 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 45 | 64% |
Unspecified | 1 | 1% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Environmental Science | 1 | 1% |
Materials Science | 1 | 1% |
Other | 1 | 1% |
Unknown | 20 | 29% |