Chapter title |
Probiotics for Prevention and Treatment of Clostridium difficile Infection
|
---|---|
Chapter number | 10 |
Book title |
Updates on Clostridium difficile in Europe
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-72799-8_10 |
Pubmed ID | |
Book ISBNs |
978-3-31-972798-1, 978-3-31-972799-8
|
Authors |
Lorena Valdés-Varela, Miguel Gueimonde, Patricia Ruas-Madiedo, Valdés-Varela, Lorena, Gueimonde, Miguel, Ruas-Madiedo, Patricia |
Abstract |
Probiotics have been claimed as a valuable tool to restore the balance in the intestinal microbiota following a dysbiosis caused by, among other factors, antibiotic therapy. This perturbed environment could favor the overgrowth of Clostridium difficile and, in fact, the occurrence of C. difficile-associated infections (CDI) is being increasing in recent years. In spite of the high number of probiotics able to in vitro inhibit the growth and/or toxicity of this pathogen, its application for treatment or prevention of CDI is still scarce since there are not enough well-defined clinical studies supporting efficacy. Only a few strains, such as Lactobacillus rhamnosus GG and Saccharomyces boulardii have been studied in more extent. The increasing knowledge about the probiotic mechanisms of action against C. difficile, some of them reviewed here, makes promising the application of these live biotherapeutic agents against CDI. Nevertheless, more effort must be paid to standardize the clinical studied conducted to evaluate probiotic products, in combination with antibiotics, in order to select the best candidate for C. difficile infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 15% |
Student > Master | 7 | 13% |
Student > Ph. D. Student | 6 | 11% |
Student > Bachelor | 4 | 8% |
Other | 4 | 8% |
Other | 10 | 19% |
Unknown | 14 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 19% |
Agricultural and Biological Sciences | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 9% |
Unknown | 15 | 28% |