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Stress-induced reproductive arrest in Drosophila occurs through ETH deficiency-mediated suppression of oogenesis and ovulation

Overview of attention for article published in BMC Biology, January 2018
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Title
Stress-induced reproductive arrest in Drosophila occurs through ETH deficiency-mediated suppression of oogenesis and ovulation
Published in
BMC Biology, January 2018
DOI 10.1186/s12915-018-0484-9
Pubmed ID
Authors

Matthew R. Meiselman, Timothy G. Kingan, Michael E. Adams

Abstract

Environmental stressors induce changes in endocrine state, leading to energy re-allocation from reproduction to survival. Female Drosophila melanogaster respond to thermal and nutrient stressors by arresting egg production through elevation of the steroid hormone ecdysone. However, the mechanisms through which this reproductive arrest occurs are not well understood. Here we report that stress-induced elevation of ecdysone is accompanied by decreased levels of ecdysis triggering hormone (ETH). Depressed levels of circulating ETH lead to attenuated activity of its targets, including juvenile hormone-producing corpus allatum and, as we describe here for the first time, octopaminergic neurons of the oviduct. Elevation of steroid thereby results in arrested oogenesis, reduced octopaminergic input to the reproductive tract, and consequent suppression of ovulation. ETH mitigates heat or nutritional stress-induced attenuation of fecundity, which suggests that its deficiency is critical to reproductive adaptability. Our findings indicate that, as a dual regulator of octopamine and juvenile hormone release, ETH provides a link between stress-induced elevation of ecdysone levels and consequent reduction in fecundity.

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The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 18%
Student > Bachelor 9 15%
Researcher 8 13%
Student > Master 7 11%
Student > Doctoral Student 3 5%
Other 10 16%
Unknown 14 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 32%
Agricultural and Biological Sciences 15 24%
Neuroscience 6 10%
Medicine and Dentistry 2 3%
Nursing and Health Professions 1 2%
Other 4 6%
Unknown 14 23%