↓ Skip to main content

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients

Overview of attention for article published in Cochrane database of systematic reviews, January 2008
Altmetric Badge

Citations

dimensions_citation
138 Dimensions

Readers on

mendeley
57 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients
Published in
Cochrane database of systematic reviews, January 2008
DOI 10.1002/14651858.cd005258.pub2
Pubmed ID
Authors

Kakkos, Stavros K, Caprini, Joseph A, Geroulakos, George, Nicolaides, Andrew N, Stansby, Gerard P, Reddy, Daniel J

Abstract

It has been suggested that combined modalities (methods of treatment) are more effective than single modalities in preventing venous thromboembolism (defined as deep vein thrombosis and pulmonary embolism, or both) in high-risk patients. To assess the efficacy of intermittent pneumatic leg compression combined with pharmacological prophylaxis versus single modalities in preventing venous thromboembolism in high-risk patients. The Cochrane Peripheral Vascular Diseases (PVD) Group searched their Specialized Register (last searched 17 July 2007) and the Cochrane Central Register of Controlled Trials (CENTRAL) (last searched The Cochrane Library 2008, Issue 3). We searched the reference lists of relevant articles to identify additional trials. Randomized controlled trials (RCTs) or controlled clinical trials (CCTs) of combined intermittent pneumatic leg compression and pharmacological interventions used to prevent venous thromboembolism in high-risk patients. Data extraction was undertaken independently by two review authors using data extraction sheets. Eleven studies, six of them randomized controlled trials, were identified. The trials included 7431 patients, in total. Compared with compression alone, the use of combined modalities reduced significantly the incidence of both symptomatic pulmonary embolism (PE) (from about 3% to 1%; odds ratio (OR) 0.39, 95% confidence interval (CI) 0.25 to 0.63) and deep vein thrombosis (DVT) (from about 4% to 1%; OR 0.43, 95% CI 0.24 to 0.76). Compared with pharmacological prophylaxis alone, the use of combined modalities significantly reduced the incidence of DVT (from 4.21% to 0.65%; OR 0.16, 95% CI 0.07 to 0.34) but the included studies were underpowered with regard to PE. The comparison of compression plus pharmacological prophylaxis versus compression plus aspirin showed a non-significant reduction in PE and DVT in favor of the former group. Repeat analysis restricted to the RCTs confirmed the above findings. Compared with compression alone, combined prophylactic modalities decrease significantly the incidence of venous thromboembolism. Compared with pharmacological prophylaxis alone, combined modalities reduce significantly the incidence of DVT but the effect on PE is unknown. The results of the current review support, especially in high-risk patients, the use of combined modalities. More studies on their role in PE prevention, compared with pharmacological prophylaxis alone, are urgently needed.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 7%
Australia 1 2%
Italy 1 2%
Spain 1 2%
France 1 2%
Unknown 49 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 26%
Student > Bachelor 9 16%
Student > Master 8 14%
Student > Postgraduate 7 12%
Other 5 9%
Other 9 16%
Unknown 4 7%
Readers by discipline Count As %
Medicine and Dentistry 35 61%
Nursing and Health Professions 5 9%
Agricultural and Biological Sciences 3 5%
Neuroscience 2 4%
Psychology 1 2%
Other 1 2%
Unknown 10 18%