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Global health trials methodological research agenda: results from a priority setting exercise

Overview of attention for article published in Trials, February 2018
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Title
Global health trials methodological research agenda: results from a priority setting exercise
Published in
Trials, February 2018
DOI 10.1186/s13063-018-2440-y
Pubmed ID
Authors

Anna Rosala-Hallas, Aneel Bhangu, Jane Blazeby, Louise Bowman, Mike Clarke, Trudie Lang, Mona Nasser, Nandi Siegfried, Karla Soares-Weiser, Matt R. Sydes, Duolao Wang, Junhua Zhang, Paula R. Williamson

Abstract

Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities, however, may not be reflected in the needs of similar research in low- to middle-income countries (LMICs) with different healthcare provision, resources and research infrastructure. The aim of the study was to identify the top priorities for methodological research in LMICs to inform further research and ultimately to improve clinical trials in these regions. An online, two-round survey was conducted from December 2016 to April 2017 amongst researchers and methodologists working on trials in LMICs. The first round required participants to suggest between three and six topics which they felt were priorities for trial methodological research in LMICs. The second round invited participants to grade the importance of a compulsory list of topics suggested by four or more individuals, and an optional list of the remaining topics. Rounds 1 and 2 were completed by 412 and 314 participants, respectively. A wide spread of years of experience, discipline, current country of residence, origin of trials training and area of involvement in trials was reported. The topics deemed most important for methodological research were: choosing appropriate outcomes to measure and training of research staff. By presenting these top priorities we have the foundations of a global health trials methodological research agenda which we hope will foster future research in specific areas in order to increase and improve trials in LMICs.

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Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 78 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 27%
Student > Master 11 14%
Student > Ph. D. Student 9 11%
Student > Doctoral Student 9 11%
Other 2 3%
Other 6 8%
Unknown 21 27%
Readers by discipline Count As %
Medicine and Dentistry 22 28%
Nursing and Health Professions 8 10%
Social Sciences 6 8%
Business, Management and Accounting 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 6 8%
Unknown 30 38%