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Clinical consequences of submicroscopic malaria parasitaemia in Uganda

Overview of attention for article published in Malaria Journal, February 2018
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Title
Clinical consequences of submicroscopic malaria parasitaemia in Uganda
Published in
Malaria Journal, February 2018
DOI 10.1186/s12936-018-2221-9
Pubmed ID
Authors

Shereen Katrak, Patience Nayebare, John Rek, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses Kamya, Grant Dorsey, Philip J. Rosenthal, Bryan Greenhouse

Abstract

Submicroscopic malaria parasitaemia is common in both high- and low-endemicity settings, but its clinical consequences are unclear. A cohort of 364 children (0.5-10 years of age) and 106 adults was followed from 2011 to 2016 in Tororo District, Uganda using passive surveillance for malaria episodes and active surveillance for parasitaemia. Participants presented every 90 days for routine visits (n = 9075); a subset was followed every 30 days. Participants who presented with fever and a positive blood smear were treated for malaria. At all routine visits microscopy was performed and samples from subjects with a negative blood smear underwent loop-mediated isothermal amplification for detection of plasmodial DNA. Submicroscopic parasitaemia was common; the proportion of visits with submicroscopic parasitemia was 25.8% in children and 39.2% in adults. For children 0.5-10 years of age, but not adults, having microscopic and submicroscopic parasitaemia at routine visits was significantly associated with both fever (adjusted risk ratios [95% CI], 2.64 [2.16-3.22], 1.67 [1.37-2.03]) and non-febrile illness (aRR [CI], 1.52 [1.30-1.78], 1.26 [1.09-1.47]), compared to not having parasitaemia. After stratifying by age, significant associations were seen between submicroscopic parasitaemia and fever in children aged 2-< 5 and 5-10 years (aRR [CI], 1.42 [1.03-1.98], 2.01 [1.49-2.71]), and submicroscopic parasitaemia and non-febrile illness in children aged 5-10 years (aRR [CI], 1.44 [1.17-1.78]). These associations were maintained after excluding individuals with a malaria episode within the preceding 14 or following 7 days, and after adjusting for household wealth. Submicroscopic malaria infections were associated with fever and non-febrile illness in Ugandan children. These findings support malaria control strategies that target low-density infections.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 77 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 14%
Student > Master 11 14%
Student > Ph. D. Student 10 13%
Researcher 9 12%
Student > Doctoral Student 6 8%
Other 6 8%
Unknown 24 31%
Readers by discipline Count As %
Medicine and Dentistry 19 25%
Biochemistry, Genetics and Molecular Biology 7 9%
Agricultural and Biological Sciences 7 9%
Immunology and Microbiology 6 8%
Nursing and Health Professions 2 3%
Other 7 9%
Unknown 29 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2018.
All research outputs
#14,294,371
of 24,400,706 outputs
Outputs from Malaria Journal
#3,527
of 5,827 outputs
Outputs of similar age
#221,894
of 445,397 outputs
Outputs of similar age from Malaria Journal
#84
of 127 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,397 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.