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Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis

Overview of attention for article published in Phytochemistry, April 2018
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Mentioned by

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1 tweeter

Citations

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11 Dimensions

Readers on

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23 Mendeley
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Title
Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
Published in
Phytochemistry, April 2018
DOI 10.1016/j.phytochem.2018.01.016
Pubmed ID
Authors

Gordana Krstić, Milka Jadranin, Nina M. Todorović, Milica Pešić, Tijana Stanković, Ivana S. Aljančić, Vele V. Tešević

Abstract

Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 26%
Student > Master 2 9%
Professor > Associate Professor 2 9%
Researcher 2 9%
Other 1 4%
Other 4 17%
Unknown 6 26%
Readers by discipline Count As %
Chemistry 5 22%
Medicine and Dentistry 3 13%
Biochemistry, Genetics and Molecular Biology 2 9%
Chemical Engineering 1 4%
Unspecified 1 4%
Other 2 9%
Unknown 9 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2018.
All research outputs
#7,825,458
of 12,470,921 outputs
Outputs from Phytochemistry
#3,866
of 4,464 outputs
Outputs of similar age
#192,305
of 339,644 outputs
Outputs of similar age from Phytochemistry
#5
of 25 outputs
Altmetric has tracked 12,470,921 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,464 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,644 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.