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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors
|
|---|---|
| Published in |
Breast Cancer Research, January 2018
|
| DOI | 10.1186/s13058-018-0933-y |
| Pubmed ID | |
| Authors |
Anneleen Daemen, Gerard Manning |
| Abstract |
Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We set out to understand the genomics of HER2 amplification independent of subtype, and the underlying drivers and biology of HER2E tumors. We investigated published genomic data from 3155 breast tumors and 5391 non-breast tumors. HER2 amplification is a distinct driver event seen in all breast cancer subtypes, rather than a subtype marker, with major characteristics restricted to amplification and overexpression of HER2 and neighboring genes. The HER2E subtype has a distinctive transcriptional landscape independent of HER2A that reflects androgen receptor signaling as replacement for estrogen receptor (ER)-driven tumorigenesis. HER2 amplification is also an event in 1.8% of non-breast tumors. These discoveries reveal therapeutic opportunities for combining anti-HER2 therapy with anti-androgen agents in breast cancer, and highlight the potential for broader therapeutic use of HER2 inhibitors. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 40% |
| Spain | 3 | 7% |
| Australia | 2 | 5% |
| Ecuador | 2 | 5% |
| India | 1 | 2% |
| Greece | 1 | 2% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Bulgaria | 1 | 2% |
| Italy | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 10 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 20 | 47% |
| Members of the public | 19 | 44% |
| Practitioners (doctors, other healthcare professionals) | 4 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Researcher | 10 | 14% |
| Student > Bachelor | 10 | 14% |
| Student > Master | 9 | 12% |
| Other | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 16 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 22% |
| Medicine and Dentistry | 12 | 16% |
| Agricultural and Biological Sciences | 11 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 17 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#1,126,941
of 25,746,891 outputs
Outputs from Breast Cancer Research
#90
of 2,068 outputs
Outputs of similar age
#26,142
of 451,672 outputs
Outputs of similar age from Breast Cancer Research
#1
of 18 outputs
Altmetric has tracked 25,746,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,068 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.