Title |
Temperature Dependence of Erythromelalgia Mutation L858F in Sodium Channel Nav1.7
|
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Published in |
Molecular Pain, January 2007
|
DOI | 10.1186/1744-8069-3-3 |
Pubmed ID | |
Authors |
Chongyang Han, Angelika Lampert, Anthony M Rush, Sulayman D Dib-Hajj, Xiaoliang Wang, Yong Yang, Stephen G Waxman |
Abstract |
The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by cooling of the limbs. Inherited erythromelalgia has recently been linked to mutations in the gene SCN9A, which encodes the voltage-gated sodium channel Nav1.7. Nav1.7 is preferentially expressed in most nociceptive DRG neurons and in sympathetic ganglion neurons. It has recently been shown that several disease-causing erythromelalgia mutations alter channel-gating behavior in a manner that increases DRG neuron excitability. |
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