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Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis?

Overview of attention for article published in British Journal of Dermatology, May 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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8 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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11 Dimensions

Readers on

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14 Mendeley
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Title
Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis?
Published in
British Journal of Dermatology, May 2018
DOI 10.1111/bjd.16428
Pubmed ID
Authors

T. Kanni, O. Zenker, M. Habel, N. Riedemann, E.J. Giamarellos-Bourboulis

Abstract

Despite the heavy purulence observed in hidradenitis suppurativa (HS), kinetics of complement anaphylatoxins acting to prime chemotaxis of neutrophils has never been studied. Complement activation was explored in HS. Circulating concentrations of complement factor C5a as well as of membrane attack complex C5b-9 were determined in the plasma of 54 treatment naïve patients and of 14 healthy controls as well as in the pus of seven patients. Results were correlated with Hurley stage and iHS4 score of severity. Peripheral blood mononuclear cells (PBMCs) were isolated form seven Hurley III stage patients and seven healthy volunteers and stimulated in the presence of 25% of plasma for the production of tumor necrosis factor-alpha (TNFα). Circulating C5a and C5b-9 were significantly greater in patient than in control plasma; however concentrations in pus were very low. Circulating C5a levels exceeding 28 ng/ml were associated with specificity greater than 90% with occurrence of HS. Circulating C5a and C5b-9 were greater among the more severe patients. PBMCs of patients produced great TNFα concentrations only when growth medium was enriched with patient plasma; this was reversed with the addition of the C5a blocker IFX-1. Systemic complement activation occurs in HS and may be used as a surrogate biomarker of HS. C5a stimulates over-production of TNFα and may be a future therapeutic target. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 36%
Student > Master 3 21%
Researcher 3 21%
Student > Ph. D. Student 1 7%
Librarian 1 7%
Other 1 7%
Readers by discipline Count As %
Unspecified 4 29%
Medicine and Dentistry 4 29%
Agricultural and Biological Sciences 3 21%
Immunology and Microbiology 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2019.
All research outputs
#2,821,575
of 12,876,256 outputs
Outputs from British Journal of Dermatology
#1,133
of 6,271 outputs
Outputs of similar age
#87,792
of 343,554 outputs
Outputs of similar age from British Journal of Dermatology
#55
of 339 outputs
Altmetric has tracked 12,876,256 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,271 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 339 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.