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Mendeley readers
Attention Score in Context
| Title |
SLC45A3-ELK4 Is a Novel and Frequent Erythroblast Transformation–Specific Fusion Transcript in Prostate Cancer
|
|---|---|
| Published in |
Cancer Research, April 2009
|
| DOI | 10.1158/0008-5472.can-08-4926 |
| Pubmed ID | |
| Authors |
David S. Rickman, Dorothee Pflueger, Benjamin Moss, Vanessa E. VanDoren, Chen X. Chen, Alexandre de la Taille, Rainer Kuefer, Ashutosh K. Tewari, Sunita R. Setlur, Francesca Demichelis, Mark A. Rubin |
| Abstract |
Chromosomal rearrangements account for all erythroblast transformation-specific (ETS) family member gene fusions that have been reported in prostate cancer and have clinical, diagnostic, and prognostic implications. Androgen-regulated genes account for the majority of the 5' genomic regulatory promoter elements fused with ETS genes. TMPRSS2-ERG, TMPRSS2-ETV1, and SLC45A3-ERG rearrangements account for roughly 90% of ETS fusion prostate cancer. ELK4, another ETS family member, is androgen regulated, involved in promoting cell growth, and highly expressed in a subset of prostate cancer, yet the mechanism of ELK4 overexpression is unknown. In this study, we identified a novel ETS family fusion transcript, SLC45A3-ELK4, and found it to be expressed in both benign prostate tissue and prostate cancer. We found high levels of SLC45A3-ELK4 mRNA restricted to a subset of prostate cancer samples. SLC45A3-ELK4 transcript can be detected at high levels in urine samples from men at risk for prostate cancer. Characterization of the fusion mRNA revealed a major variant in which SLC45A3 exon 1 is fused to ELK4 exon 2. Based on quantitative PCR analyses of DNA, unlike other ETS fusions described in prostate cancer, the expression of SLC45A3-ELK4 mRNA is not exclusive to cases harboring a chromosomal rearrangement. Treatment of LNCaP cancer cells with a synthetic androgen (R1881) revealed that SLC45A3-ELK4, and not endogenous ELK4, mRNA expression is androgen regulated. Altogether, our findings show that SLC45A3-ELK4 mRNA expression is heterogeneous, highly induced in a subset of prostate cancers, androgen regulated, and most commonly occurs through a mechanism other than chromosomal rearrangement (e.g., trans-splicing). |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Norway | 1 | 1% |
| Hungary | 1 | 1% |
| Canada | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 91 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 31% |
| Student > Ph. D. Student | 27 | 28% |
| Student > Master | 8 | 8% |
| Professor | 6 | 6% |
| Other | 6 | 6% |
| Other | 13 | 13% |
| Unknown | 8 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 39% |
| Biochemistry, Genetics and Molecular Biology | 25 | 26% |
| Medicine and Dentistry | 14 | 14% |
| Computer Science | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 12 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2023.
All research outputs
#1,997,567
of 22,785,242 outputs
Outputs from Cancer Research
#1,452
of 17,867 outputs
Outputs of similar age
#6,251
of 94,069 outputs
Outputs of similar age from Cancer Research
#11
of 205 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,069 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 205 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.