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Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats

Overview of attention for article published in BMC Complementary and Alternative Medicine, February 2018
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

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1 tweeter
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1 Wikipedia page

Citations

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9 Dimensions

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28 Mendeley
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Title
Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats
Published in
BMC Complementary and Alternative Medicine, February 2018
DOI 10.1186/s12906-018-2110-3
Pubmed ID
Authors

Nashwan Abdullah Al-Afifi, Aied Mohammed Alabsi, Marina Mohd Bakri, Anand Ramanathan

Abstract

Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications. In acute oral toxicity test, DC resin methanol extract administered to female Sprague Dawley rats by oral gavage at a single dose of 300 and 2000 mg/kg body weight. Rats observed for toxic signs for 14 days. In sub-acute oral toxicity test, DC resin methanol extract administered to the rats by oral gavage at 500, 1000, and 1500 mg/kg body weight daily up to 28 days to male and female Spradgue Dawley rats. The control and high dose in satellite groups were also maintained and handled as the previous groups to determine the late onset toxicity of DC resin methanol extract. At the end of each test, hematological and biochemical analysis of the collected blood were performed as well as gross and microscopic pathology. In acute oral toxicity, no treatment-related death or toxic signs were observed. It revealed that the DC resin methanol extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. The sub-acute test observations indicated that there are no treatment-related changes up to the high dose level compared to the control. Food consumption, body weight, organ weight, hematological parameters, biochemical parameters and histopathological examination (liver, kidney, heart, spleen and lung) revealed no abnormalities. Water intake was significantly higher in the DC resin methanol extract treated groups compared to the control. This study demonstrates tolerability of DC resin methanol extract administered daily for 28 days up to 1500 mg/kg dose.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 21%
Student > Bachelor 5 18%
Student > Ph. D. Student 4 14%
Student > Doctoral Student 2 7%
Other 1 4%
Other 3 11%
Unknown 7 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 25%
Medicine and Dentistry 5 18%
Pharmacology, Toxicology and Pharmaceutical Science 4 14%
Agricultural and Biological Sciences 2 7%
Veterinary Science and Veterinary Medicine 1 4%
Other 1 4%
Unknown 8 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2018.
All research outputs
#3,656,405
of 12,884,059 outputs
Outputs from BMC Complementary and Alternative Medicine
#783
of 2,619 outputs
Outputs of similar age
#117,320
of 343,431 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 12,884,059 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,619 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,431 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them