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A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana

Overview of attention for article published in BMC Biology, February 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

blogs
1 blog
twitter
40 tweeters
facebook
1 Facebook page

Citations

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14 Dimensions

Readers on

mendeley
47 Mendeley
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Title
A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana
Published in
BMC Biology, February 2018
DOI 10.1186/s12915-018-0490-y
Pubmed ID
Authors

Thomas Stanislas, Matthieu Pierre Platre, Mengying Liu, Léa E. S. Rambaud-Lavigne, Yvon Jaillais, Olivier Hamant

Abstract

In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other, allowing the production of organs during the entire post-embryonic life of the plant. Transcription factors, microRNA, hormones, peptides and forces have been involved in meristem function. Whereas phosphatidylinositol phosphates (PIPs) have been involved in almost all biological functions, including stem cell maintenance and organogenesis in animals, the processes in meristem biology to which PIPs contribute still need to be delineated. Using biosensors for PI4P and PI(4,5)P2, the two most abundant PIPs at the plasma membrane, we reveal that meristem functions are associated with a stereotypical PIP tissue-scale pattern, with PI(4,5)P2 always displaying a more clear-cut pattern than PI4P. Using clavata3 and pin-formed1 mutants, we show that stem cell maintenance is associated with reduced levels of PIPs. In contrast, high PIP levels are signatures for organ-meristem boundaries. Interestingly, this pattern echoes that of cortical microtubules and stress anisotropy at the meristem. Using ablations and pharmacological approaches, we further show that PIP levels can be increased when the tensile stress pattern is altered. Conversely, we find that katanin mutant meristems, with increased isotropy of microtubule arrays and slower response to mechanical perturbations, exhibit reduced PIP gradients within the SAM. Comparable PIP pattern defects were observed in phospholipase A3β overexpressor lines, which largely phenocopy katanin mutants at the whole plant level. Using phospholipid biosensors, we identified a stereotypical PIP accumulation pattern in the SAM that negatively correlates with stem cell maintenance and positively correlates with organ-boundary establishment. While other cues are very likely to contribute to the final PIP pattern, we provide evidence that the patterns of PIP, cortical microtubules and mechanical stress are positively correlated, suggesting that the PIP pattern, and its reproducibility, relies at least in part on the mechanical status of the SAM.

Twitter Demographics

The data shown below were collected from the profiles of 40 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 28%
Student > Ph. D. Student 11 23%
Student > Master 6 13%
Student > Bachelor 3 6%
Student > Doctoral Student 1 2%
Other 2 4%
Unknown 11 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 55%
Biochemistry, Genetics and Molecular Biology 8 17%
Nursing and Health Professions 1 2%
Social Sciences 1 2%
Engineering 1 2%
Other 0 0%
Unknown 10 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2019.
All research outputs
#698,161
of 16,141,869 outputs
Outputs from BMC Biology
#195
of 1,389 outputs
Outputs of similar age
#24,216
of 369,060 outputs
Outputs of similar age from BMC Biology
#1
of 2 outputs
Altmetric has tracked 16,141,869 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them