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Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro

Overview of attention for article published in Cancer Research, December 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

patent
2 patents
wikipedia
6 Wikipedia pages

Citations

dimensions_citation
240 Dimensions

Readers on

mendeley
171 Mendeley
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Title
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro
Published in
Cancer Research, December 2006
DOI 10.1158/0008-5472.can-06-2066
Pubmed ID
Authors

Meredith T. Morgan, Yuka Nakanishi, David J. Kroll, Aaron P. Griset, Michael A. Carnahan, Michel Wathier, Nicholas H. Oberlies, Govindarajan Manikumar, Mansukh C. Wani, Mark W. Grinstaff

Abstract

A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC(50) values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle.

Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 3 2%
Russia 1 <1%
Denmark 1 <1%
Egypt 1 <1%
Unknown 165 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 28%
Student > Master 29 17%
Researcher 26 15%
Student > Bachelor 20 12%
Professor > Associate Professor 9 5%
Other 16 9%
Unknown 23 13%
Readers by discipline Count As %
Chemistry 50 29%
Agricultural and Biological Sciences 29 17%
Engineering 14 8%
Pharmacology, Toxicology and Pharmaceutical Science 13 8%
Biochemistry, Genetics and Molecular Biology 12 7%
Other 28 16%
Unknown 25 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2022.
All research outputs
#4,350,167
of 21,429,365 outputs
Outputs from Cancer Research
#4,323
of 17,399 outputs
Outputs of similar age
#63,452
of 322,187 outputs
Outputs of similar age from Cancer Research
#39
of 123 outputs
Altmetric has tracked 21,429,365 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,399 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.