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Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco

Overview of attention for article published in BMC Biotechnology, March 2009
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4 Wikipedia pages

Citations

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31 Dimensions

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51 Mendeley
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Title
Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco
Published in
BMC Biotechnology, March 2009
DOI 10.1186/1472-6750-9-22
Pubmed ID
Authors

Luisa Bortesi, Marzia Rossato, Flora Schuster, Nicole Raven, Johannes Stadlmann, Linda Avesani, Alberto Falorni, Flavia Bazzoni, Ralph Bock, Stefan Schillberg, Mario Pezzotti

Abstract

Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, with therapeutic applications in several autoimmune and inflammatory diseases. Oral administration of this cytokine alone, or in combination with disease-associated autoantigens could confer protection form the onset of a specific autoimmune disease through the induction of oral tolerance. Transgenic plants are attractive systems for production of therapeutic proteins because of the ability to do large scale-up at low cost, and the low maintenance requirements. They are highly amenable to oral administration and could become effective delivery systems without extensive protein purification. We investigated the ability of tobacco plants to produce high levels of biologically-active viral and murine IL-10.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
United States 1 2%
Sweden 1 2%
Argentina 1 2%
Unknown 47 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 24%
Student > Master 9 18%
Student > Ph. D. Student 7 14%
Professor > Associate Professor 7 14%
Other 5 10%
Other 7 14%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 53%
Biochemistry, Genetics and Molecular Biology 6 12%
Medicine and Dentistry 5 10%
Engineering 3 6%
Environmental Science 1 2%
Other 4 8%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2020.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from BMC Biotechnology
#427
of 935 outputs
Outputs of similar age
#32,819
of 94,252 outputs
Outputs of similar age from BMC Biotechnology
#7
of 12 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 935 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.