Title |
Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco
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Published in |
BMC Biotechnology, March 2009
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DOI | 10.1186/1472-6750-9-22 |
Pubmed ID | |
Authors |
Luisa Bortesi, Marzia Rossato, Flora Schuster, Nicole Raven, Johannes Stadlmann, Linda Avesani, Alberto Falorni, Flavia Bazzoni, Ralph Bock, Stefan Schillberg, Mario Pezzotti |
Abstract |
Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, with therapeutic applications in several autoimmune and inflammatory diseases. Oral administration of this cytokine alone, or in combination with disease-associated autoantigens could confer protection form the onset of a specific autoimmune disease through the induction of oral tolerance. Transgenic plants are attractive systems for production of therapeutic proteins because of the ability to do large scale-up at low cost, and the low maintenance requirements. They are highly amenable to oral administration and could become effective delivery systems without extensive protein purification. We investigated the ability of tobacco plants to produce high levels of biologically-active viral and murine IL-10. |
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Geographical breakdown
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Spain | 1 | 2% |
United States | 1 | 2% |
Sweden | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 47 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 24% |
Student > Master | 9 | 18% |
Student > Ph. D. Student | 7 | 14% |
Professor > Associate Professor | 7 | 14% |
Other | 5 | 10% |
Other | 7 | 14% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Medicine and Dentistry | 5 | 10% |
Engineering | 3 | 6% |
Environmental Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 5 | 10% |