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Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

Overview of attention for article published in Molecular Cancer, October 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

policy
1 policy source
patent
18 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
324 Dimensions

Readers on

mendeley
146 Mendeley
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Title
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
Published in
Molecular Cancer, October 2006
DOI 10.1186/1476-4598-5-50
Pubmed ID
Authors

Jennifer AA Gubbels, Jennifer Belisle, Masanori Onda, Claudine Rancourt, Martine Migneault, Mitchell Ho, Tapan K Bera, Joseph Connor, Bangalore K Sathyanarayana, Byungkook Lee, Ira Pastan, Manish S Patankar

Abstract

The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kinetics of the binding between these two glycoproteins are not clearly understood. Here we have addressed this deficit and provide further evidence supporting the role of the MUC16-mesothelin interaction in facilitating cell-cell binding under conditions that mimic the peritoneal environment.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Germany 1 <1%
Unknown 143 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 21%
Student > Ph. D. Student 26 18%
Student > Bachelor 16 11%
Student > Master 11 8%
Student > Postgraduate 8 5%
Other 20 14%
Unknown 35 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 21%
Medicine and Dentistry 29 20%
Biochemistry, Genetics and Molecular Biology 23 16%
Chemistry 6 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 13 9%
Unknown 39 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#1,744,014
of 23,267,128 outputs
Outputs from Molecular Cancer
#80
of 1,754 outputs
Outputs of similar age
#3,177
of 69,109 outputs
Outputs of similar age from Molecular Cancer
#1
of 9 outputs
Altmetric has tracked 23,267,128 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,754 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,109 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them