↓ Skip to main content

Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE

Overview of attention for article published in American Journal of Neuroradiology, February 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 2,898)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

twitter
54 tweeters
facebook
4 Facebook pages

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
12 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE
Published in
American Journal of Neuroradiology, February 2018
DOI 10.3174/ajnr.a5534
Pubmed ID
Authors

E.S. Beck, P. Sati, V. Sethi, T. Kober, B. Dewey, P. Bhargava, G. Nair, I.C. Cortese, D.S. Reich, Beck, E S, Sati, P, Sethi, V, Kober, T, Dewey, B, Bhargava, P, Nair, G, Cortese, I C, Reich, D S

Abstract

Cortical lesions are common and often extensive in multiple sclerosis but are difficult to visualize by MRI, leaving important questions about their clinical implications and response to therapy unanswered. Our aim was to determine whether cortical lesions are better visualized using magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) than T2*-weighted imaging on 7T MR imaging. Brain MR imaging using T1-weighted MP2RAGE at 500-μm isotropic resolution, T2*-weighted gradient-echo, and T2*-weighted segmented echo-planar imaging sequences were collected for 13 patients with MS and 5 age-matched neurologically healthy controls on a 7T research system. One MS case underwent postmortem MR imaging including gradient-echo and MP2RAGE sequences, after which cortical lesions seen on MR imaging were assessed with immunohistochemistry. MP2RAGE detected 203 cortical lesions (median, 16 lesions/case; interquartile range, 15), compared to 92 with T2*gradient-echo (median, 7; interquartile range, 8;P< .001) and 81 with T2*EPI (median, 7; interquartile range, 5;P< .001). This increase in lesion number detected on MP2RAGE versus T2* was observed for juxtacortical, leukocortical, and intracortical lesions. Forty-three percent of all cortical lesions were identified only on MP2RAGE. White matter lesion volume correlated with total juxtacortical (r= 0.86,P< .001) and leukocortical lesion volume (r= 0.70,P< .01) but not intracortical lesion volume, suggesting that pathophysiology may differ by lesion type. Of 4 suspected lesions seen on postmortem imaging, 3 were found to be true cortical lesions while 1 represented postmortem tissue damage. A combination of MP2RAGE and T2*-weighted imaging at 7T improved detection of cortical lesions and should enable longitudinal studies to elucidate their spatiotemporal dynamics and clinical implications.

Twitter Demographics

The data shown below were collected from the profiles of 54 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 17%
Student > Ph. D. Student 2 17%
Researcher 2 17%
Unspecified 2 17%
Professor 1 8%
Other 3 25%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Unspecified 3 25%
Physics and Astronomy 2 17%
Psychology 1 8%
Neuroscience 1 8%
Other 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#319,819
of 11,662,003 outputs
Outputs from American Journal of Neuroradiology
#20
of 2,898 outputs
Outputs of similar age
#17,272
of 306,346 outputs
Outputs of similar age from American Journal of Neuroradiology
#1
of 84 outputs
Altmetric has tracked 11,662,003 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,898 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.