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Cyclophosphamide and cancer: golden anniversary

Overview of attention for article published in Nature Reviews Clinical Oncology, September 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
patent
5 patents
wikipedia
8 Wikipedia pages

Citations

dimensions_citation
672 Dimensions

Readers on

mendeley
646 Mendeley
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Title
Cyclophosphamide and cancer: golden anniversary
Published in
Nature Reviews Clinical Oncology, September 2009
DOI 10.1038/nrclinonc.2009.146
Pubmed ID
Authors

Ashkan Emadi, Richard J. Jones, Robert A. Brodsky

Abstract

Cyclophosphamide remains one of the most successful and widely utilized antineoplastic drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation (BMT). It was initially synthesized to selectively target cancer cells, although the hypothesized mechanism of tumor specificity (activation by cancer cell phosphamidases) transpired to be irrelevant to its activity. Nevertheless, cyclophosphamide's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties. Differential cellular expression of aldehyde dehydrogenase has an effect on the anticancer therapeutic index and immunosuppressive properties of cyclophosphamide. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of cyclophosphamide in cancer and autoimmune disorders. We also discuss the development of high-dose cyclophosphamide for BMT and the treatment of autoimmune diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 646 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 <1%
Belgium 2 <1%
United States 2 <1%
Iran, Islamic Republic of 1 <1%
Netherlands 1 <1%
Russia 1 <1%
France 1 <1%
Unknown 636 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 96 15%
Student > Bachelor 93 14%
Student > Master 74 11%
Researcher 71 11%
Other 32 5%
Other 108 17%
Unknown 172 27%
Readers by discipline Count As %
Medicine and Dentistry 113 17%
Biochemistry, Genetics and Molecular Biology 99 15%
Agricultural and Biological Sciences 74 11%
Pharmacology, Toxicology and Pharmaceutical Science 54 8%
Chemistry 32 5%
Other 74 11%
Unknown 200 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#2,539,849
of 24,584,609 outputs
Outputs from Nature Reviews Clinical Oncology
#583
of 2,154 outputs
Outputs of similar age
#8,246
of 98,197 outputs
Outputs of similar age from Nature Reviews Clinical Oncology
#1
of 7 outputs
Altmetric has tracked 24,584,609 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,154 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,197 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them