Title |
Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive–compulsive disorder
|
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Published in |
Proceedings of the National Academy of Sciences of the United States of America, February 2018
|
DOI | 10.1073/pnas.1716686115 |
Pubmed ID | |
Authors |
Nicco Reggente, Teena D. Moody, Francesca Morfini, Courtney Sheen, Jesse Rissman, Joseph O’Neill, Jamie D. Feusner |
Abstract |
Cognitive behavioral therapy (CBT) is an effective treatment for many with obsessive-compulsive disorder (OCD). However, response varies considerably among individuals. Attaining a means to predict an individual's potential response would permit clinicians to more prudently allocate resources for this often stressful and time-consuming treatment. We collected resting-state functional magnetic resonance imaging from adults with OCD before and after 4 weeks of intensive daily CBT. We leveraged machine learning with cross-validation to assess the power of functional connectivity (FC) patterns to predict individual posttreatment OCD symptom severity. Pretreatment FC patterns within the default mode network and visual network significantly predicted posttreatment OCD severity, explaining up to 67% of the variance. These networks were stronger predictors than pretreatment clinical scores. Results have clinical implications for developing personalized medicine approaches to identifying individual OCD patients who will maximally benefit from intensive CBT. |
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Geographical breakdown
Country | Count | As % |
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United States | 5 | 28% |
United Kingdom | 3 | 17% |
Australia | 1 | 6% |
Canada | 1 | 6% |
China | 1 | 6% |
Unknown | 7 | 39% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 56% |
Scientists | 5 | 28% |
Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 218 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 53 | 24% |
Researcher | 30 | 14% |
Student > Bachelor | 20 | 9% |
Student > Master | 19 | 9% |
Student > Doctoral Student | 15 | 7% |
Other | 32 | 15% |
Unknown | 49 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 54 | 25% |
Neuroscience | 40 | 18% |
Medicine and Dentistry | 13 | 6% |
Engineering | 6 | 3% |
Nursing and Health Professions | 5 | 2% |
Other | 27 | 12% |
Unknown | 73 | 33% |