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Biomarker responses of Peromyscus leucopus exposed to lead and cadmium in the Southeast Missouri Lead Mining District

Overview of attention for article published in Environmental Monitoring & Assessment, January 2018
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Title
Biomarker responses of Peromyscus leucopus exposed to lead and cadmium in the Southeast Missouri Lead Mining District
Published in
Environmental Monitoring & Assessment, January 2018
DOI 10.1007/s10661-017-6442-0
Pubmed ID
Authors

W. Nelson Beyer, Stan W. Casteel, Kristen R. Friedrichs, Eric Gramlich, Ruth A. Houseright, John R. Nichols, Natalie K. Karouna-Renier, Dae Young Kim, Kathleen L. Rangen, Barnett A. Rattner, Sandra L. Schultz

Abstract

Biomarker responses and histopathological lesions have been documented in laboratory mammals exposed to elevated concentrations of lead and cadmium. The exposure of white-footed mice (Peromyscus leucopus) to these metals and the potential associated toxic effects were examined at three contaminated sites in the Southeast Missouri Lead Mining District and at a reference site in MO, USA. Mice from the contaminated sites showed evidence of oxidative stress and reduced activity of red blood cell δ-aminolevulinic acid dehydratase (ALAD). Histological examinations of the liver and kidney, cytologic examination of blood smears, and biomarkers of lipid peroxidation and DNA damage failed to show indications of toxic effects from lead. The biomagnification factor of cadmium (hepatic concentration/soil concentration) at a site with a strongly acid soil was 44 times the average of the biomagnification factors at two sites with slightly alkaline soils. The elevated concentrations of cadmium in the mice did not cause observable toxicity, but were associated with about a 50% decrease in expected tissue lead concentrations and greater ALAD activity compared to the activity at the reference site. Lead was associated with a decrease in concentrations of hepatic glutathione and thiols, whereas cadmium was associated with an increase. In addition, to support risk assessment efforts, we developed linear regression models relating both tissue lead dosages (based on a previously published a laboratory study) and tissue lead concentrations in Peromyscus to soil lead concentrations.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 14%
Other 2 14%
Student > Master 2 14%
Unknown 8 57%
Readers by discipline Count As %
Environmental Science 2 14%
Agricultural and Biological Sciences 2 14%
Immunology and Microbiology 1 7%
Earth and Planetary Sciences 1 7%
Medicine and Dentistry 1 7%
Other 0 0%
Unknown 7 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2018.
All research outputs
#11,154,430
of 12,538,691 outputs
Outputs from Environmental Monitoring & Assessment
#979
of 1,218 outputs
Outputs of similar age
#294,536
of 347,104 outputs
Outputs of similar age from Environmental Monitoring & Assessment
#41
of 52 outputs
Altmetric has tracked 12,538,691 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,218 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.