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Proteomic analysis of the shistosome tegument and its surface membranes

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, October 2006
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

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2 Wikipedia pages


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89 Mendeley
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Proteomic analysis of the shistosome tegument and its surface membranes
Published in
Memórias do Instituto Oswaldo Cruz, October 2006
DOI 10.1590/s0074-02762006000900032
Pubmed ID

Simon Braschi, William Castro Borges, R Alan Wilson


The tegument surface of the adult schistosome, bounded by a normal plasma membrane overlain by a secreted membranocalyx, holds the key to understanding how schistosomes evade host immune responses. Recent advances in mass spectrometry (MS), and the sequencing of the Schistosoma mansoni transcriptome/genome, have facilitated schistosome proteomics. We detached the tegument from the worm body and enriched its surface membranes by differential extraction, before subjecting the preparation to liquid chromatography-based proteomics to identify its constituents. The most exposed proteins on live worms were labelled with impearmeant biotinylation reagents, and we also developed methods to isolate the membranocalyx for analysis. We identified transporters for sugars, amino acids, inorganic ions and water, which confirm the importance of the tegument plasma membrane in nutrient acquisition and solute balance. Enzymes, including phosphohydrolases, esterases and carbonic anhydrase were located with their catalytic domains external to the plasma membrane, while five tetraspanins, annexin and dysferlin were implicated in membrane architecture. In contrast, few parasite proteins could be assigned to the membranocalyx but mouse immune response proteins, including three immunoglobulins and two complement factors, were detected, plus host membrane proteins such as CD44, integrin and a complement regulatory protein, testifying to the acquisitive properties of the secreted bilayer.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 3%
United Kingdom 2 2%
Australia 1 1%
Switzerland 1 1%
Unknown 82 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 27%
Researcher 13 15%
Student > Master 13 15%
Student > Bachelor 7 8%
Professor 5 6%
Other 15 17%
Unknown 12 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 51%
Medicine and Dentistry 9 10%
Biochemistry, Genetics and Molecular Biology 5 6%
Immunology and Microbiology 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 8 9%
Unknown 15 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2021.
All research outputs
of 4,655,094 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
of 85 outputs
Outputs of similar age
of 161,031 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
of 2 outputs
Altmetric has tracked 4,655,094 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 85 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,031 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them