Title |
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
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Published in |
Genome Biology, February 2009
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DOI | 10.1186/gb-2009-10-2-r21 |
Pubmed ID | |
Authors |
Neekesh V Dharia, Amar Bir Singh Sidhu, María Belén Cassera, Scott J Westenberger, Selina ER Bopp, Rich T Eastman, David Plouffe, Serge Batalov, Daniel J Park, Sarah K Volkman, Dyann F Wirth, Yingyao Zhou, David A Fidock, Elizabeth A Winzeler |
Abstract |
The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the development of new therapeutic agents, and provide information about the likely function of genes. Elucidating mechanisms of phenotypic drug resistance can also assist in identifying the mode of action of uncharacterized but potent antimalarial compounds identified in high-throughput chemical screening campaigns against Plasmodium falciparum. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Switzerland | 1 | 1% |
Burkina Faso | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 93 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 31% |
Researcher | 24 | 24% |
Student > Master | 9 | 9% |
Professor | 7 | 7% |
Professor > Associate Professor | 6 | 6% |
Other | 15 | 15% |
Unknown | 7 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 48% |
Biochemistry, Genetics and Molecular Biology | 16 | 16% |
Chemistry | 9 | 9% |
Medicine and Dentistry | 6 | 6% |
Veterinary Science and Veterinary Medicine | 2 | 2% |
Other | 9 | 9% |
Unknown | 9 | 9% |